Continuous subcutaneous insulin infusion methods with a hyaluronan-degrading enzyme
First Claim
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1. A method of controlling blood glucose in a subject by continuous subcutaneous insulin infusion (CSII) therapy, comprising:
- a) administering a composition comprising a hyaluronan-degrading enzyme to the subject; and
thenb) continuously infusing a fast-acting insulin by CSII to the subject, wherein the difference in insulin absorption is minimized or reduced over the course of infusion set life compared to CSII performed in the absence of the hyaluronan-degrading enzyme.
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Abstract
Provided are methods for continuous subcutaneous insulin infusion (CSII) that employ a hyaluronan-degrading enzyme, including a recombinant human PH20 (rHuPH20). The methods can be used to more consistently control blood glucose during the course of CSII. The methods can be used to treat subjects having diabetes or other insulin-associated disease or condition.
66 Citations
39 Claims
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1. A method of controlling blood glucose in a subject by continuous subcutaneous insulin infusion (CSII) therapy, comprising:
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a) administering a composition comprising a hyaluronan-degrading enzyme to the subject; and
thenb) continuously infusing a fast-acting insulin by CSII to the subject, wherein the difference in insulin absorption is minimized or reduced over the course of infusion set life compared to CSII performed in the absence of the hyaluronan-degrading enzyme. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A continuous subcutaneous insulin infusion (CSII) dosage regimen method for controlling blood glucose in a subject, comprising:
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a) performing CSII to deliver a composition comprising a super fast-acting insulin composition to a subject in accord with a programmed basal rate and bolus dose of insulin; and b) at least once during the course of treatment, increasing the amount of basal insulin and/or bolus insulin administered by at least 1% compared to the programmed basal rate and bolus dose of insulin administered in the absence of a hyaluronan-degrading enzyme thereby increasing insulin action. - View Dependent Claims (35, 36, 37, 38, 39)
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Specification