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VARIANTS OF HUMANIZED IMMUNOMODULATORY MONOCLONAL ANTIBODIES

  • US 20130022595A1
  • Filed: 07/23/2012
  • Published: 01/24/2013
  • Est. Priority Date: 07/24/2011
  • Status: Active Grant
First Claim
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1. An antibody or antigen binding fragment thereof comprising a light chain variable region selected from the group consisting of SEQ ID NO:

  • 1, 2, 3, and 4, and a heavy chain variable region selected from the group consisting of SEQ ID NO;

    5, 6, 7, 8, and 9, wherein the antibody or antigen binding fragment thereof comprises at least one amino acid substitution at a position selected from;

    Phe 97 and Phe 93 of the light chain variable region to Ala, Leu or Val, or a substitution of Trp 107 of the heavy chain variable region to Ala, Leu, Val or Tyr.

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