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Controlled Release Formulations of Opioids

  • US 20130022646A1
  • Filed: 04/09/2012
  • Published: 01/24/2013
  • Est. Priority Date: 02/09/2010
  • Status: Abandoned Application
First Claim
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1. A pharmaceutical formulation for treatment of pain in a human, comprising a controlled release component, wherein:

  • (a) the controlled release component comprises one or more cores;

    (b) the controlled release component comprises oxycodone;

    (c) the pharmaceutical formulation comprises a steady state plasma concentration profile of the oxycodone having a fluctuation index of about 90% or less; and

    (d) the pharmaceutical formulation, when containing a total dose of about 20 mg of oxycodone and administered at a dosing interval of 12 hours, will produce an AUCss,τ

    that is about 100 ng*h/mL to about 550 ng*h/mL.

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