DELAYED PROLONGED DRUG DELIVERY
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Accused Products
Abstract
In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released in a prolonged manner at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released whilst a subject is sleeping, shortly before waking and continues to administer the drug during the early waking hours. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for a delayed, followed by a prolonged release of drug.
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Citations
37 Claims
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1-16. -16. (canceled)
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17. A press-coated tablet formulation for a delayed, followed by a prolonged release of an active agent, the tablet comprising
(a) a core comprising the active agent together with a wax and optionally one or more fillers; - and
(b) a delayed release layer surrounding the core and comprising a wax and LH-32 in a ratio of 20;
80 to 50;
50 w/w;
wherein the delayed release layer substantially delays release of the active agent within the core for between 2-8 hours after administration of the tablet by a subject and thereafter a prolonged release of the active agent from the core occurs, such that the active agent in the core is continuously released over a period of up to 2-8 hours. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 31)
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- 28. A press-coated tablet comprising a cardiovascular agent for treating a cardiovascular condition, wherein the tablet is intended to be administered immediately prior to a subject going to sleep and wherein the cardiovascular agent is substantially not released from the tablet for a period between 2-8 hours after administration of the tablet to the subject and thereafter the agent is released from the tablet in a prolonged manner such that the agent within the tablet is released continuously over a period of up to 2-8 hours.
- 30. A method of treating a cardiovascular condition, the method comprising administering a press-coated tablet comprising a cardiovascular agent, to a subject, immediately before the subject intends sleeping, wherein the formulation substantially delays release of the drug for 2-8 hours following administration of the formulation and thereafter the cardiovascular agent is released continuously over a period of up to 2-8 hours.
Specification