DEVICE AND METHOD FOR MONITORING PHYSIOLOGICAL SIGNALS

• US 20130023740A1
• Filed: 06/26/2012
• Published: 01/24/2013
• Est. Priority Date: 07/21/2011
• Status: Abandoned Application

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik SE & Company KG
• Inventors: Kirchner, Jens, Skerl, Olaf
• Application Number:
  US13/532,959
• Publication Number:
  US 20130023740A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61N 1/36535 controlled by body position or posture

Abstract

An implantable device includes a posture sensor and a physiological signal sensor. The posture sensor supplies at least one first sensor output signal indicating body posture and/or changes therein. The physiological signal sensor supplies at least one second sensor output signal indicative of at least one physiological parameter such as blood pressure, intracardiac impedance, stroke volume, heart sounds, heart rate, and/or biochemical measurements (e.g., oxygen concentration). An evaluation unit processes the first and second sensor output signals and determines one or more variables that describe the dynamic behavior of the second sensor output signal in response to a change in body posture indicated by the first sensor output signal.

Claims

1. A monitoring device including:

a. a posture sensor configured to provide a first sensor output signal indicating at least one of;

(1) body posture, and

(2) a change in body posture,

b. a physiological signal sensor configured to provide a second sensor output signal indicating a value of a physiological parameter;

c. an evaluation unit configured to determine at least one variable characterizing the dynamic behavior of the second sensor output signal in response to a change in body posture indicated by the first sensor output signal.

2. The monitoring device of claim 1 wherein the physiological parameter includes at least one of:

a. blood pressure,

b. intracardiac impedance,

c. stroke volume,

d. heart sounds,

e. heart rate, and

f. oxygen concentration.

3. The monitoring device of claim 1 wherein the posture sensor is a 3D acceleration sensor.

4. The monitoring device of claim 1 wherein the evaluation unit is designed to identify, from the first sensor output signal, a time of a change in a body posture.

5. The monitoring device of claim 1 wherein the physiological signal sensor is a blood pressure sensor.

6. The monitoring device of claim 1 wherein the physiological signal sensor is an impedance sensor.

7. The monitoring device of claim 1 wherein the physiological signal sensor is configured to initiate provision of the second sensor output signal upon or following a change in body posture indicated by the first sensor output signal.

8. The monitoring device of claim 1 wherein the evaluation unit is configured to:

a. divide the second sensor output signal into sub-intervals ordered in succession over time, and

b. further determine, for one or more of the sub-segments, at least one variable characterizing the dynamic behavior of the second sensor output signal during each sub-interval.

9. The monitoring device of claim 8 wherein the evaluation unit is further configured to determine a duration of a sub-interval of the second sensor output signal.

10. The monitoring device of claim 1 wherein the evaluation unit is configured to quantify a delay between:

a. a value of the first sensor output signal indicative of a change in body posture, and

b. the start of a change of the second output signal.

11. The monitoring device of claim 1 wherein the evaluation unit is configured to quantify a slope of the second sensor output signal following a value of the first sensor output signal indicative of a change in body posture.

12. The monitoring device of claim 1 wherein the evaluation unit is configured to determine a duration required for the second sensor output signal to pass through a given second sensor output signal difference.

13. The monitoring device of claim 1 wherein the evaluation unit is configured to:

a. fit a model function to the second sensor output signal, and

b. identify one or more function parameters characterizing the model function.

14. The monitoring device of claim 1 wherein the monitoring device is a cardiac stimulator.

15. A monitoring method including the following steps:

a. at least substantially continuously measuring a first sensor output signal indicating at least one of;

(1) body posture, and

(2) a change in body posture,

b. detecting a change in body posture indicated by the first sensor output signal;

c. measuring a second sensor output signal indicating a value of a physiological parameter;

d. calculating at least one variable characterizing the dynamic behavior of the second sensor output signal in response to a change in body posture indicated by the first sensor output signal.

16. The monitoring method of claim 15 wherein the physiological parameter includes at least one of:

a. blood pressure,

b. intracardiac impedance,

c. stroke volume,

d. heart sounds,

e. heart rate, and

f. oxygen concentration.

17. The monitoring method of claim 15 further including the step of initiating measurement of the second sensor output signal upon or following a change in body posture indicated by the first sensor output signal.

18. The monitoring method of claim 15 wherein the calculated variable characterizing the dynamic behavior of the second sensor output signal is a parameter characterizing a fit of a model function to at least a portion of the second sensor output signal.

19. The monitoring method of claim 18 wherein the model function is an exponential function.

20. A monitoring device including:

a. a posture sensor;

b. a physiological signal sensor;

c. an evaluation unit configured to;

(1) receive from the posture sensor a first sensor output signal characterizing body posture;

(2) receive from the physiological signal sensor a second sensor output signal characterizing one or more of;

(a) blood pressure,

(b) blood flow,

(c) stroke volume,

(d) heart sounds,

(e) heart rate, and

(f) oxygen concentration, and

(b) intracardiac impedance;

(3) characterize the behavior of the second sensor output signal in response to a change in body posture indicated by the first sensor output signal.