MEDICAMENT DELIVERY DEVICES FOR ADMINISTRATION OF A MEDICAMENT WITHIN A PREFILLED SYRINGE

• US 20130023825A1
• Filed: 01/25/2012
• Published: 01/24/2013
• Est. Priority Date: 01/26/2011
• Status: Active Grant

• Current Assignee: Kaleo, Inc.
• Original Assignee: Intelliject Incorporated
• Inventors: Edwards, Eric S., Edwards, Evan T., Licata, Mark J., Meyers, Paul F.
• Granted Patent: US 9,084,849 B2
• Time in Patent Office: Days
• US Class Current: 604/143
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/208 Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
• CPC Class Codes: A61M 2005/2086 having piston damping means, e.g. axially or rotationally acting retarders
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

An apparatus includes a housing, a medicament container and a movable member. The medicament container is configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member is configured to exert the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member is configured to exert a retraction force on the flange to move the medicament container from the second position towards the first position.

Claims

1. An apparatus, comprising:

a housing;

a medicament container configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member, a proximal end portion of the medicament container including a flange and having a plunger disposed therein; and

a movable member configured to move within the housing, a first shoulder of the movable member configured to exert at least a portion of the force on the flange to move the medicament container from the first position to the second position, a portion of the first shoulder configured to deform when the medicament container is in the second position such that the portion of the force is exerted upon the plunger, a second shoulder of the movable member configured to exert a retraction force on the flange to move the medicament container from the second position towards the first position.

2. The apparatus of claim 1, further comprising:

a damping member disposed between the first shoulder of the movable member and the flange of the medicament container.

3. The apparatus of claim 1, further comprising:

a damping member disposed between the second shoulder of the movable member and the flange of the medicament container.

4. The apparatus of claim 1, further comprising:

a retraction spring configured to produce the retraction force to move the medicament container from its second position to a third position.

5. The apparatus of claim 1, wherein the medicament container is configured to move from the first position to the second position in a first direction, the apparatus further comprising:

a retraction spring coupled to the movable member, the retraction spring configured to produce the retraction force to move the movable member in a second direction.

6. The apparatus of claim 5, wherein the refraction spring and the movable member are monolithically constructed.

7. The apparatus of claim 1, further comprising:

the energy storage member, the energy storage member being any one of a spring, a container configured to produce a pressurized gas or a device configured to store electrical energy.

8. The apparatus of claim 1, wherein the movable member includes a piston portion disposed within the medicament container, the piston portion spaced apart from the plunger when the medicament container is in the first position, the piston portion in contact with the plunger after the portion of the first shoulder is deformed.

9. The apparatus of claim 1, further comprising:

a piston coupled to the movable member, at least a portion of the piston disposed within the medicament container, the portion of the piston disposed apart from the plunger when the medicament container is in the first position, the portion of the piston in contact with the plunger after the portion of the first shoulder is deformed.

10. The apparatus of claim 1, wherein the movable member is a first movable member, the apparatus further comprising:

a second movable member configured to move with the medicament container when the medicament container moves from the first position to the second position, the second movable member configured to move relative to the medicament container to expel a medicament from the medicament container after the portion of the first shoulder is deformed.

11. The apparatus of claim 1, wherein the movable member is configured to move with the medicament container when the medicament container moves from the first position to the second position, the movable member configured to move relative to the medicament container to expel a medicament from the medicament container after the portion of the first shoulder is deformed.

12. The apparatus of claim 1, further comprising:

a piston coupled to the movable member, the piston is configured to move with the medicament container when the medicament container moves from the first position to the second position, the piston configured to move relative to the medicament container to expel a medicament from the medicament container after the portion of the first shoulder is deformed.

13. The apparatus of claim 1, wherein the medicament container is a prefilled syringe containing at least one of influenza A vaccine, influenza B vaccine, influenza A (H1N1) vaccine, hepatitis A vaccine, hepatitis B vaccine, haemophilus influenza Type B (HiB) vaccine, measles vaccine, mumps vaccine, rubella vaccine, polio vaccine, human papilloma virus (HPV) vaccine, tetanus vaccine, diphtheria vaccine, pertussis vaccine, bubonic plague vaccine, yellow fever vaccine, cholera vaccine, malaria vaccine, smallpox vaccine, pneumococcal vaccine, rotavirus vaccine, varicella vaccine, rabies vaccine, meningococcus vaccine, epinephrine, salicylic acid, naloxone, naltrexone, buprenorphine, diazepam, lorazepam, midazolam, testosterone, vitamin D, vitamin B12, diphenhydramine, hydroxyzine, risperidone, haloperidol, hyaluronidase, sumatriptan, methotrexate, insulin, glucagon, exenatide, C1 esterase inhibitor, kallikrein inhibitor, bradykinin B2 inhibitor, human growth hormone (HGH), erythropoietin alfa/epoetin alfa, imiglucerase, darbepoetin alfa, denosumab, golimumab, adalimumab, certolizumab, ustekinumab, canakinumab, interferons (interferon-alpha-2a, interferon-alpha-2b, interferon-beta 1a, interferon-beta-1b, and their pegylated forms) etanercept, pegfilgrastim, enoxaparin, semuloparin, or dalteparin.

14. The apparatus of claim 1, wherein a distal end portion of the medicament container is coupled to a needle, the needle disposed within the housing when the medicament container is in the first position, at least a portion of the needle is disposed outside of the housing when the medicament container is in the second position.

15. The apparatus of claim 1, wherein:

the medicament container is configured to move from the first position to the second position in a first direction; and

the movable member includes a protrusion configured to engage a portion of the housing when the medicament container is in the first position to limit movement of the medicament container in a second direction.

16. The apparatus of claim 1, further comprising:

an electronic circuit system, at least one of a portion of the movable member, a safety lock or a system actuator configured to actuate the electronic circuit system.

17. An apparatus, comprising:

a housing;

a medicament container configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member, a proximal end portion of the medicament container including a flange and having a plunger disposed therein; and

a movable member configured to exert the force on the medicament container to move the medicament container from the first position to the second position, an engagement portion of the movable member configured to limit movement of a piston surface relative to the plunger when the medicament container moves from the first position to the second position such that the piston surface is spaced apart from the plunger, the engagement portion configured to deform when the medicament container is in the second position such that the piston surface is in contact with the plunger.

18. The apparatus of claim 17, wherein the movable member includes a shoulder configured to contact the flange of the medicament container to exert the force on the medicament container to move the medicament container from the first position to the second position.

19. The apparatus of claim 17, wherein the movable member includes a shoulder configured to exert a refraction force on the flange to move the medicament container from the second position towards the first position.

20. The apparatus of claim 17, wherein the movable member includes the piston surface.

21. The apparatus of claim 17, further comprising:

a piston member coupled to the movable member, the piston member including the piston surface.

22. The apparatus of claim 17, further comprising:

a damping member disposed between the movable member and the flange of the medicament container.

23. The apparatus of claim 17, wherein the force produced by the energy storage member is a first force, the medicament container configured to move from the first position to the second position in a first direction, the apparatus further comprising:

a retraction spring coupled to the movable member, the retraction spring configured to produce a second force to move the movable member in a second direction.

24. The apparatus of claim 17, wherein the movable member is a first movable member, the apparatus further comprising:

a second movable member configured to move with the medicament container when the medicament container moves from the first position to the second position, the second movable member configured to move relative to the medicament container to expel a medicament from the medicament container after the engagement portion of the movable member is deformed.

25. An apparatus, comprising:

a housing;

a medicament container configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member, a proximal end portion of the medicament container including a flange and having a plunger disposed therein;

a first movable member configured to move within the housing, the first movable member operably coupled to the energy storage member such that a first portion of the first movable member is configured to exert the force on the flange to move the medicament container from the first position to the second position, a second portion of the first movable member configured to deform when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger; and

a second movable member configured to move with the medicament container when the medicament container moves from the first position to the second position, the second movable member configured to move relative to the medicament container to move the plunger within the medicament container after the second portion of the first movable member is deformed.

26. The apparatus of claim 25, wherein a third portion of the first movable member is configured to exert a refraction force on the flange to move the medicament container from the second position towards the first position.

27. The apparatus of claim 25, wherein the force produced by the energy storage member is a first force, the medicament container configured to move from the first position to the second position in a first direction, the apparatus further comprising:

a retraction spring coupled to the first movable member, the retraction spring configured to produce a second force to move the first movable member in a second direction.

28. The apparatus of claim 25, wherein the first movable member includes a piston portion disposed within the medicament container, the piston portion spaced apart from the plunger when the medicament container is moved from the first position to the second position, the piston portion in contact with the plunger when the portion of the first shoulder is deformed.

29. The apparatus of claim 25, wherein a longitudinal axis of the second movable member is offset from a longitudinal axis of the first movable member.

30. The apparatus of claim 25, wherein:

a longitudinal axis of the first movable member is offset from a longitudinal axis of the energy storage member; and

a first portion of the second movable member is in contact with the energy storage member, a second portion of the second movable member is in contact with the first movable when the medicament container moves from the first position to the second position.

31. The apparatus of claim 25, wherein:

the second movable member includes a piston portion disposed within the medicament container, the piston portion disposed apart from the plunger when the medicament container moves from the first position to the second position, the piston portion in contact with the plunger after the second portion of the first movable member is deformed.

32. An apparatus, comprising:

a carrier configured to be disposed within a housing of a medical device, the carrier configured to contain at least a proximal portion of a medicament container having a flange such that a first shoulder of the carrier is in contact with a proximal surface of the flange and a second shoulder of the carrier is in contact with a distal surface of the flange,

the carrier having a first engagement portion configured to engage a movable member such that when a first force is exerted by the movable member on the first engagement portion, the first shoulder transfers at least a portion of the first force to the proximal surface of the flange,

the carrier having a second engagement portion configured to engage a retraction spring such that when a second force is exerted by the retraction spring on the second engagement portion, the second shoulder transfers at least a portion of the second force to the distal surface of the flange.

33. The apparatus of claim 32, wherein the carrier has a first portion and a second portion hingedly coupled to the first portion, the first portion and the second portion substantially surrounding the proximal portion of the medicament container when the carrier is in a first configuration, the second portion spaced apart from the first portion such that the medicament container can be removed from carrier when the carrier is in a second configuration.

34. The apparatus of claim 32, further comprising:

the medicament container; and

a damping member disposed between the first shoulder of the carrier and the proximal surface of the flange of the medicament container.

35. The apparatus of claim 32, further comprising:

the medicament container; and

a damping member disposed between the second shoulder of the carrier and the proximal surface of the flange of the medicament container.

36. The apparatus of claim 32, wherein the carrier includes a crush rib configured to deform when carrier moves into contact with a wall of the housing.

37. The apparatus of claim 32, further comprising:

the medicament container having a plunger disposed therein; and

the movable member coupled to the carrier such that the first engagement portion of the carrier is disposed against a shoulder of the movable member and at least a portion of the movable member is disposed within the medicament container.

38. The apparatus of claim 37, wherein the first engagement portion is configured to deform when the first force exceeds a threshold value such that the movable member moves relative to the medicament container.

39. The apparatus of claim 32, wherein:

the carrier includes a third engagement portion configured to engage a portion of the housing to limit movement of the carrier within the housing.

40. An apparatus, comprising:

a movable member configured to be disposed within a housing of a medical device, the movable member having a first engagement portion, a second engagement portion and a retraction portion, the first engagement portion configured to be coupled to an energy storage member,

the second engagement portion configured to be coupled to a medicament container such that a shoulder of the second engagement portion exerts a first force produced by the energy storage member on the medicament container to move the medicament container within the housing in a first direction,

the retraction portion configured to produce a second force to move the medicament container within the housing in a second direction.

41. The apparatus of claim 40, wherein the first engagement portion is configured to be releasably coupled to the energy storage member.

42. The apparatus of claim 40, wherein a portion of the shoulder of the second engagement portion is configured to contact a flange of the medicament container when the second engagement portion is in a first configuration, the portion of the shoulder of the second engagement portion is configured to be disposed within the medicament container when the second engagement portion is in a second configuration.

43. The apparatus of claim 42, wherein the shoulder of the second engagement portion is configured deform when the second engagement portion is moved from the first configuration to the second configuration.

44. The apparatus of claim 40, wherein the retraction portion includes a spring.

45. The apparatus of claim 40, wherein the retraction portion includes a spring, the spring and at least the second engagement portion being monolithically constructed.