OCULAR DRUG DELIVERY DEVICE

• US 20130023838A1
• Filed: 09/17/2012
• Published: 01/24/2013
• Est. Priority Date: 08/26/2003
• Status: Active Grant

• Current Assignee: Amorphex Therapeutics Llc
• Original Assignee: Vista Scientific, LLC
• Inventors: Leahy, Charles D., Labombard, Denis
• Granted Patent: US 8,679,078 B2
• Time in Patent Office: Days
• US Class Current: 604/294
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics

Abstract

An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery device and contains an active pharmaceutical agent, a lubricant, etc.

Claims

1. An ocular device for delivery of a therapeutic agent to the eye comprising:

a preformed body having an anterior surface and an opposite posterior surface for placement on the sclera of the eye, the posterior surface having a preformed curved shape outside of the eye that is defined by a base curve shaped to fit the sclera;

wherein the preformed body is configured to be held on the sclera such that the preformed body is free of contact with and spaced from a cornea of the eye.

2. The ocular device of claim 1, wherein the posterior surface includes a first section that is defined by the base curve and an adjacent second section at peripheral edges of the body that is defined by edge lift radii;

wherein the posterior surface is shaped to fit the sclera of the eye so as to permit the device to be held on the eye by fluid attraction and be retained on the eye without aid of an eyelid.

3. The ocular device of claim 1, wherein the body includes a central portion with a first edge that faces the cornea of the eye when the body is placed on the sclera, the first edge having an inwardly curved shape.

4. The ocular device of claim 3, wherein the first edge has a shape corresponding approximately to a projection of a corneal perimeter.

5. The ocular device of claim 3, wherein the central portion includes a second edge, opposite the first edge, that is further from the cornea when the body is placed on the sclera, the second edge having an inwardly curved shape, the curvature of the second edge being different than the curvature of the first edge.

6. The ocular device of claim 1, wherein the preformed body of the ocular device is constructed to be held on a tear film of the sclera by fluid attraction and maintained in a held state thereon such that the preformed body remains free of contact with and spaced from the cornea.

7. The ocular device of claim 1, wherein the posterior surface is configured for placement on one of a superior sclera and inferior sclera of the eye.

8. An ocular device for delivery of a therapeutic agent to the eye comprising:

a preformed body having an anterior surface and an opposite posterior surface for placement on the sclera of the eye, the posterior surface having a preformed curved shape outside of the eye that is shaped to fit the sclera;

wherein the preformed body has one or more lobes, each lobe having a horizontal width and height greater than a horizontal width and height, respectively, of a peripheral edge of the preformed body, wherein the increased size of the lobe maintains positioning and stability of the preformed body on the eye through interaction with an eyelid of the eye.