DETERMINATION OF A LIPID WATER RATIO
First Claim
1. An apparatus (100) for determining a lipid-water ratio in an associated sample, comprisinga light source (S), anda light detector (PD),the light source (S) and the light detector (PD) being arranged to measure an optical parameter of the sample at a limited number of selected and distinct wavelengths, and arranged to measure a first, second and third optical parameter at the selected and distinct wavelengths lambda_1, lambda_2 and lambda_3, respectively,wherein an optical absorption coefficient for water at lambda_1 is substantially similar to an optical absorption coefficient for water at lambda_2 and an optical absorption coefficient for lipids at lambda_1 is substantially similar to an optical absorption coefficient for lipids at lambda_2, andwherein the apparatus is capable of determining a lipid-water ratio of the sample based on the first and second optical parameters measured at lambda_1 and lambda_2 and the third optical parameter measured at lambda_3.
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Accused Products
Abstract
The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.
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Citations
15 Claims
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1. An apparatus (100) for determining a lipid-water ratio in an associated sample, comprising
a light source (S), and a light detector (PD), the light source (S) and the light detector (PD) being arranged to measure an optical parameter of the sample at a limited number of selected and distinct wavelengths, and arranged to measure a first, second and third optical parameter at the selected and distinct wavelengths lambda_1, lambda_2 and lambda_3, respectively, wherein an optical absorption coefficient for water at lambda_1 is substantially similar to an optical absorption coefficient for water at lambda_2 and an optical absorption coefficient for lipids at lambda_1 is substantially similar to an optical absorption coefficient for lipids at lambda_2, and wherein the apparatus is capable of determining a lipid-water ratio of the sample based on the first and second optical parameters measured at lambda_1 and lambda_2 and the third optical parameter measured at lambda_3.
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11. A method for determining a lipid-water ratio in a sample, the method comprising the steps of
measuring (S1) a first optical parameter at a first selected and distinct wavelength lambda_1, measuring (S2) a second optical parameter at a second selected and distinct wavelength lambda_2, measuring (S3) a third optical parameter at a third selected and distinct wavelength lambda_3, and determining (S4) a scattering parameter based on the first optical parameter and the second optical parameter, and determining (S5) a lipid-water ratio based on the scattering parameter and the third optical parameter wherein an optical absorption coefficient for water at lambda_1 is substantially similar to an optical absorption coefficient for water at lambda_2 and an optical absorption coefficient for lipids at lambda_1 is substantially similar to an optical absorption coefficient for lipids at lambda_2.
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14. A computer program product being adapted to enable a computer system comprising at least one computer having data storage means associated therewith to operate a processor arranged for
receiving information (101) derived from a first optical parameter measured at a first selected and distinct wavelength lambda_1, receiving information (102) derived from a second optical parameter measured at a second selected and distinct wavelength lambda_2, receiving information (103) derived from a third optical parameter measured at a third selected and distinct wavelength lambda_3, calculating a scattering parameter (sp) based on the information (101) derived from the first optical parameter and the information (102) derived from the second optical parameter, and calculating a lipid-water ratio (lw) based on information (sp) derived from the scattering parameter and information (103) derived from the third optical parameter, wherein an optical absorption coefficient for water at lambda_1 is substantially similar to an optical absorption coefficient for water at lambda_2 and an optical absorption coefficient for lipids at lambda_1 is substantially similar to an optical absorption coefficient for lipids at lambda_2.
Specification