MIXING DEVICE, MIXING TUBE, DRUG SOLUTION INJECTING SYSTEM, AND DRUG SOLUTION MIXING METHOD

• US 20130028841A1
• Filed: 03/28/2011
• Published: 01/31/2013
• Est. Priority Date: 04/05/2010
• Status: Active Grant

• Current Assignee: Nemoto Kyorindo Company Limited
• Original Assignee: Nemoto Kyoridno Company Limited
• Inventors: Park, Young Kwang, Yagi, Takanobu, Umezu, Mitsuo
• Granted Patent: US 9,314,749 B2
• Time in Patent Office: Days
• US Class Current: 424/9.1
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61K 49/005 characterised by the carrier molecule carrying the fluorescent agent
• CPC Class Codes: A61K 49/0071 solution, solute
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 23/451 by injecting one liquid into another
• CPC Class Codes: B01F 25/10 Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
• CPC Class Codes: B01F 25/104 characterised by the arrangement of the discharge opening

Abstract

To provide a mixing device, a mixing tube, a drug solution injecting system, and a drug solution mixing method capable of evenly and efficiently mixing a plurality of kinds of drug solutions. The mixing device according to the present invention includes: a swirling flow generating chamber; a first inflow opening for introducing a first drug solution into the swirling flow generating chamber in a direction parallel to a central axis of the swirling flow; a second inflow opening for introducing a second drug solution into the swirling flow generating chamber so as to generate a swirling flow of the second drug solution having a specific gravity lower than that of the first drug solution; an outflow opening for discharging a mixed drug solution; and a narrowing chamber which is interposed between the swirling flow generating chamber and the outflow opening and has a space continuously narrowed toward the outflow opening.

Claims

1. A mixing device comprising:

a swirling flow generating chamber adapted for generating a swirling flow;

a first inflow opening adapted for introducing a first drug solution into the swirling flow generating chamber in a direction parallel to a central axis of the swirling flow;

a second inflow opening adapted for introducing a second drug solution into the swirling flow generating chamber so as to generate a swirling flow of the second drug solution having a specific gravity lower than that of the first drug solution in the swirling flow generating chamber;

an outflow opening adapted for discharging a mixed drug solution of the first drug solution and the second drug solution; and

a narrowing chamber which is interposed between the swirling flow generating chamber and the outflow opening and has a space continuously narrowed toward the outflow opening.

2. The mixing device according to claim 1, wherein the swirling flow generating chamber has a columnar space, and

the narrowing chamber has a conical space.

3. The mixing device according to claim 1, wherein the first inflow opening is formed on an end surface in front of the swirling flow generating chamber, and

the second inflow opening is formed on a side surface of the swirling flow generating chamber.

4. The mixing device according to claim 1, wherein an inner diameter of the second inflow opening is smaller than an inner diameter of the first inflow opening.

5. The mixing device according to claim 1, wherein, inside the swirling flow generating chamber, a taper portion is formed in a boundary portion between an inside end surface in front of the swirling flow generating chamber and an inner surface of the swirling flow generating chamber.

6. The mixing device according to claim 1, wherein, inside the swirling flow generating chamber, a curved portion is formed in a boundary portion between the inside end surface in front of the swirling flow generating chamber and the inner surface of the swirling flow generating chamber.

7. The mixing device according to claim 1, wherein an inner surface of the narrowing chamber has a streamlined shape.

8. The mixing device according to claim 1, wherein the first drug solution is a contrast agent and the second drug solution is saline.

9. A mixing tube comprising:

a first tube communicated with the first inflow opening;

a second tube communicated with the second inflow opening;

a third tube communicated with the outflow opening; and

the mixing device according to claim 1.

10. A drug solution injecting system comprising:

a drug solution injecting apparatus having a head to which a first syringe filled with the first drug solution and a second syringe filled with the second drug solution are attached, and a controller connected to the head; and

the mixing tube according to claim 9, connected to the first syringe and the second syringe.

11. A drug solution mixing method comprising:

generating a swirling flow of a second drug solution;

introducing a first drug solution in a direction parallel to a central axis of the swirling flow;

guiding the first drug solution and the second drug solution into a space continuously narrowed toward an outflow opening to collide the first drug solution and the second drug solution; and

discharging a mixed drug solution of the first drug solution and the second drug solution from the outflow opening.

12. The drug solution mixing method according to claim 11, wherein the first drug solution is a contrast agent and the second drug solution is saline.