SUSTAINED RELEASE ORAL MATRIX AND METHODS OF MAKING THEREOF
First Claim
1. A solid tablet for controlled release of active medicaments comprising one or more active pharmaceutically agent in an amount sufficient to provide a therapeutic effect when administered and at least a pressures sensitive adhesive.
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Accused Products
Abstract
A solid dosage form suitable for forming a tablet for the containment and delivery of medicament is provided wherein the matrix forming material is a pressure sensitive adhesive, present in the amount from about 0.1 to about 40 weight %, based on the total weight of the composition. The dosage form is comprised of the medicament and a water-insoluble polymer silicone pressure sensitive adhesive and allows release of the medicament in a controlled fashion depending on simple parameters such as weight percent of the polymer silicone adhesive. A sustained release dosage form is provided for delivery of medicament wherein the release rate of medicament does not depend on the dissolution medium of the pH. Another aspect of invention is formation of solid tablets of poorly compressible material and the method for making the solid composition. The dosage form for this invention s particularly suitable for oral dosage forms.
13 Citations
19 Claims
- 1. A solid tablet for controlled release of active medicaments comprising one or more active pharmaceutically agent in an amount sufficient to provide a therapeutic effect when administered and at least a pressures sensitive adhesive.
- 9. A solid tablet for controlled release of active medicaments comprising one or more active pharmaceutically agent in an amount sufficient to provide a therapeutic effect when administered, an excipient and at least a pressures sensitive adhesive.
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17. A method for preparing the oral tablet comprising the steps of:
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(i) dissolving the pressure sensitive adhesive in appropriate solvent (ii) forming a suspension of medicament in the adhesive/solvent solution (iii) drying the suspension to obtain a solid matrix (iv) compressing the matrix to form required shape and size of the oral dosage form - View Dependent Claims (18)
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Specification