METHOD AND DEVICE FOR IMPROVING GLYCEMIC CONTROL

• US 20130030358A1
• Filed: 01/20/2011
• Published: 01/31/2013
• Est. Priority Date: 01/20/2010
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Medingo Ltd. (Roche Holding AG)
• Inventors: Yodfat, Ofer, Shapira, Gali, Gescheit, Iddo M.
• Granted Patent: US 9,457,145 B2
• Time in Patent Office: Days
• US Class Current: 604/66
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

Systems, devices and methods are presented in the subject disclosure for recommending an insulin dose adapted for use with an insulin delivery device. In some embodiments, the method may include receiving blood glucose (BG) data, determining one or more insulin sensitivity (IS) values associated with the BG data, and determining an insulin dose based on the determined one or more IS values. A system for carrying out such a method is also presented.

Claims

1-36. -36. (canceled)

37. A method for recommending an insulin dose adapted for use with an insulin delivery device, the method comprising:

receiving blood glucose (BC) data;

determining one or more insulin sensitivity (IS) values associated with the BG data; and

determining an insulin dose based on the determined one or more IS values.

38. The method of claim 37, wherein the BG data comprises BC level and optionally BC trend.

39. The method of claim 37, wherein receiving of BG data includes at least one of:

receiving an input from a user, and receiving a signal from a glucose monitor.

40. The method of claim 37, wherein determining the one or more IS values includes at least one of:

selecting the one or more IS values from a table, calculating the one or more IS values, modeling or correlating the one or more IS values with respect to empirical data, and matching the one or more IS values to BC data, wherein the determining establishes a relationship between the one or more IS values and the BC data.

41. The method of claim 37, further comprising visually presenting the one or more IS values as a function of BC data.

42. The method of claim 41, wherein visually presenting includes presenting a graph or a table showing matching between the one or more IS values and the BC data.

43. The method of claim 37, further comprising visually presenting the one or more IS values in a form of a range.

44. The method of claim 37, further comprising retrieving from a memory the one or more IS values associated with BG data.

45. The method of claim 37, wherein the insulin close includes at least one of a bolus component and a basal component.

46. The method of claim 37, further comprising delivering the insulin dose a body of a user.

47. The method of claim 37, further comprising providing an insulin pump having a processor having a dose advisor application operating thereon, the dose advisor being configured to determine the one or more IS values and the insulin dose, and initiating delivery of the insulin.

48. A computer program comprising instructions for carrying out the steps of the method according to claim 37 when said computer program is executed on a suitable computer device.

49. A computer readable medium having encoded thereon a computer program according to claim 48.

50. A drug delivery device comprising means adapted to carry out the steps of the method according to claims 37.

51. A drug delivery device comprising:

a pump for dispensing the drug into a body of a user;

input means for receiving at least one of blood glucose (BG) data and one or more insulin sensitivity (IS) values;

a processor having a dose advisor application operating thereon configured to determine the one or more IS values based on the BG data;

a memory for storing the BG data and the one or more IS values; and

a display for presenting output associated with the one or more IS values.

52. The device of claim 51, wherein the BG data is received from a continuous glucose monitor (CGM).

53. The device of claim 51, wherein the dose advisor generates an insulin dose recommendation associated with the one or more IS values.

54. The device of claim 51, wherein the input means includes one or more of:

at least one button/switch, a keypad, a touch-screen, a voice commander, a glucometer, and a CGM.

55. The device of claim 51, further including at least one subcutaneously insertable cannula to deliver the insulin dose recommendation.