Drug Condensation Aerosols And Kits
First Claim
1. A drug supply article comprising:
- a heat-conductive substrate having an impermeable surface;
a drug composition comprising the drug coated on at least a portion of the surface in the form of a film having a thickness; and
a heat source operable to supply heat to the substrate at a rate that achieves a temperature sufficient to vaporize all or a portion of the coated drug composition within a period of 2 seconds;
wherein the vaporized drug composition comprises a therapeutically effective amount of the drug;
wherein the film has a thickness between 0.05 and 20 microns;
wherein the drug is selected from the group consisting of alprazolam, fentanyl, loxapine, prochlorperazine and zaleplon.
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Accused Products
Abstract
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.
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Citations
15 Claims
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1. A drug supply article comprising:
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a heat-conductive substrate having an impermeable surface; a drug composition comprising the drug coated on at least a portion of the surface in the form of a film having a thickness; and a heat source operable to supply heat to the substrate at a rate that achieves a temperature sufficient to vaporize all or a portion of the coated drug composition within a period of 2 seconds; wherein the vaporized drug composition comprises a therapeutically effective amount of the drug; wherein the film has a thickness between 0.05 and 20 microns; wherein the drug is selected from the group consisting of alprazolam, fentanyl, loxapine, prochlorperazine and zaleplon. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification