SYSTEMS AND METHODS FOR DETERMINING A SUBSTANTIALLY HEMATOCRIT INDEPENDENT ANALYTE CONCENTRATION
7 Assignments
0 Petitions
Accused Products
Abstract
A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
10 Citations
25 Claims
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1-8. -8. (canceled)
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9. A method of detecting the presence of sufficient quantity of a fluid sample deposited on a test strip having a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer, the method comprising:
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applying a forward test voltage between the reference electrode and the working electrode and measuring a forward current value near the end of the forward test voltage, in which the forward test voltage is from about 100 millivolts to about 600 millivolts; applying a reverse test voltage of opposite polarity and substantially equal magnitude to the forward test voltage and measuring a reverse current value near the end of the reverse test voltage, the reverse test voltage being from about negative 100 millivolts to about negative 600 millivolts; calculating a ratio of the reverse current value to the forward current value; and determining if the ratio of the reverse current value to the forward current value is within an acceptance range, the acceptance range being substantially equal to two when the reference electrode is about twice the surface area of the working electrode. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A method of checking a functionality of a test strip having a reference electrode and a working electrode with the working electrode being coated with a reagent layer, the method comprising:
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applying a fluid sample to the test strip for a reaction period; applying a first test voltage between the reference electrode and the working electrode and measuring a first current value, in which the first test voltage is an absolute value from about 100 millivolts to about 600 millivolts; applying a first rest voltage between the reference electrode and the working electrode, the first rest voltage is an absolute value from about zero to about 50 millivolts; applying a second test voltage between the reference electrode and the working electrode and measuring a second current value, in which the second test voltage is an absolute value from about 100 millivolts to about 600 millivolts; applying a second rest voltage between the reference electrode and the working electrode, in which the second rest voltage is an absolute value from about zero to about 50 millivolts; applying a third test voltage between the reference electrode and the working electrode and measuring a third current value, in which the third test voltage is an absolute value from about 100 millivolts to about 600 millivolts; applying a third rest voltage between the reference electrode and the working electrode, in which the third rest voltage is an absolute value from about zero to about 50 millivolts; applying a fourth test voltage between the reference electrode and the working electrode and measuring a fourth current value, in which the fourth test voltage is an absolute value from about 100 millivolts to about 600 millivolts; applying a fourth rest voltage between the reference electrode and the working electrode, in which the fourth rest voltage is an absolute value from about zero to about 50 millivolts; applying a fifth test voltage between the reference electrode and the working electrode and measuring a fifth current value, in which the fifth test voltage is an absolute value from about 100 millivolts to about 600 millivolts; generating a curve representing the first, second, third, fourth and fifth current values as a function of pulse time, in which the pulse time is measured relative to initiation of the first test voltage; using least squares regression to fit the curve to the following equation; - View Dependent Claims (17)
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18. An analyte measurement system comprising:
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a test strip comprising a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer; and a test meter comprising; an electronic circuit that applies a plurality of voltages to the reference electrode and the working electrode over respective durations; and a signal processor configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
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Specification