Polysaccharide Based Hydrogels
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Abstract
Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
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Citations
181 Claims
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1-161. -161. (canceled)
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162. A hydrogel composition, comprising
a polysaccharide substrate or derivative thereof having a molecular weight of 160 Dalton to 80,300 Dalton and comprising at least two reactive nucleophilic groups; -
a synthetic, hydrophilic polymer of a molecular weight of 200 Dalton to 100,000 Dalton and comprising at least two nucleophilic reactive groups; and a crosslinking agent. - View Dependent Claims (163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177)
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178. A hydrogel composition, comprising
a polysaccharide or derivative thereof having a molecular weight of 160 Dalton to 80,300 Dalton, a degree of deacetylation greater or equal to 70%, and at least two reactive nucleophilic groups, wherein the polysaccharide or derivative thereof is soluble in an aqueous solution; -
a multifunctional, polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, at least three arms, and comprising at least two nucleophilic reactive groups; and a multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, at least three arms and comprising at least two electrophilic reactive groups. - View Dependent Claims (179)
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180. A hydrogel composition, comprising
a chitosan or derivative thereof having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation greater or equal to 70%, and at least two reactive nucleophilic groups, wherein the chitosan or derivative thereof is soluble in an aqueous solution; -
a multifunctional, polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, at least three arms, and comprising at least two nucleophilic reactive groups; and a multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, at least three arms and comprising at least two electrophilic reactive groups; wherein the hydrogel comprises ester groups to provide for deagradation via hydrolysis. - View Dependent Claims (181)
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Specification