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METHODS OF USING ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION TO TREAT TUMOR IMMUNITY

  • US 20130045201A1
  • Filed: 05/23/2012
  • Published: 02/21/2013
  • Est. Priority Date: 12/09/2008
  • Status: Abandoned Application
First Claim
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1. A method of treating a T-cell dysfunctional disorder resulting from tumor immunity comprising administering an effective amount of an anti-PD-L1 antibody or antigen binding fragment thereof, wherein the antibody or antibody fragment comprises a heavy chain and a light chain variable region sequence, wherein:

  • (a) the heavy chain comprises an HVR-H1, HVR-H2 and HVR-H3, wherein further;

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