ANTI-PD-L1 ANTIBODIES AND ARTICLES OF MANUFACTURE
First Claim
Patent Images
1. An isolated anti-PD-L1 antibody or antigen binding fragment comprising a light chain or a heavy chain variable region sequence, wherein:
- (a) the heavy chain or antigen binding fragment thereof further comprises and HVR-H1, HVR-H2 and an HVR-H3 sequence having at least 85% sequence identity to GFTFSDSWIH (SEQ ID NO;
15), AWISPYGGSTYYADSVKG (SEQ ID NO;
16) and RHWPGGFDY (SEQ ID NO;
3), respectively, or(b) the light chain or antigen binding fragment thereof further comprises an HVR-L1, HVR-L2 and an HVR-L3 sequence having at least 85% sequence identity to RASQDVSTAVA (SEQ ID NO;
17), SASFLYS (SEQ ID NO;
18) and QQYLYHPAT (SEQ ID NO;
19), respectively.
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Accused Products
Abstract
The present application relates to anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
53 Citations
45 Claims
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1. An isolated anti-PD-L1 antibody or antigen binding fragment comprising a light chain or a heavy chain variable region sequence, wherein:
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(a) the heavy chain or antigen binding fragment thereof further comprises and HVR-H1, HVR-H2 and an HVR-H3 sequence having at least 85% sequence identity to GFTFSDSWIH (SEQ ID NO;
15), AWISPYGGSTYYADSVKG (SEQ ID NO;
16) and RHWPGGFDY (SEQ ID NO;
3), respectively, or(b) the light chain or antigen binding fragment thereof further comprises an HVR-L1, HVR-L2 and an HVR-L3 sequence having at least 85% sequence identity to RASQDVSTAVA (SEQ ID NO;
17), SASFLYS (SEQ ID NO;
18) and QQYLYHPAT (SEQ ID NO;
19), respectively. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 38)
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19. An isolated anti-PD-L1 antibody or antigen binding fragment thereof, wherein the antibody or antibody fragment comprises a heavy chain and a light chain variable region sequence, wherein:
(a) the heavy chain sequence has at least 85% sequence identity to the heavy chain sequence; - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 39, 40, 41, 42, 43, 44, 45)
Specification