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ANTI-PD-L1 ANTIBODIES AND ARTICLES OF MANUFACTURE

  • US 20130045202A1
  • Filed: 05/24/2012
  • Published: 02/21/2013
  • Est. Priority Date: 12/09/2008
  • Status: Abandoned Application
First Claim
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1. An isolated anti-PD-L1 antibody or antigen binding fragment comprising a light chain or a heavy chain variable region sequence, wherein:

  • (a) the heavy chain or antigen binding fragment thereof further comprises and HVR-H1, HVR-H2 and an HVR-H3 sequence having at least 85% sequence identity to GFTFSDSWIH (SEQ ID NO;

    15), AWISPYGGSTYYADSVKG (SEQ ID NO;

    16) and RHWPGGFDY (SEQ ID NO;

    3), respectively, or(b) the light chain or antigen binding fragment thereof further comprises an HVR-L1, HVR-L2 and an HVR-L3 sequence having at least 85% sequence identity to RASQDVSTAVA (SEQ ID NO;

    17), SASFLYS (SEQ ID NO;

    18) and QQYLYHPAT (SEQ ID NO;

    19), respectively.

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