POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF
First Claim
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1. A polyetherimide composition, comprising:
- repeating units derived from one or more phenolic monomers, wherein each of the one or more phenolic monomers does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors, andone or more residual phenolic monomers present at more than zero but less than or equal to 1,000 ppmwherein when the residual phenolic monomer does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors.
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Abstract
This disclosure relates to polyetherimide compositions whose residual phenolic monomers exhibit little or no estradiol binding activity. Also disclosed are methods for making the disclosed polyetherimides and articles of manufacture comprising the disclosed polyetherimides.
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Citations
43 Claims
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1. A polyetherimide composition, comprising:
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repeating units derived from one or more phenolic monomers, wherein each of the one or more phenolic monomers does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors, and one or more residual phenolic monomers present at more than zero but less than or equal to 1,000 ppm wherein when the residual phenolic monomer does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors. - View Dependent Claims (2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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4. The polyetherimide composition of claim 4, wherein the phenolic monomer comprises a bisphenolic monomer, a mono phenolic monomer, or a combination thereof.
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18. A method for the manufacture of a polyetherimide, comprising:
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a) providing a phenolic monomer that does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors; b) providing a bis phthalimide; and c) reacting the phenolic monomer and the bis phthalimide under conditions effective to provide a polyetherimide comprising a residual phenolic monomer content of more than zero and less than 1,000 ppm, wherein the polyetherimide provided in step c) is further characterized in that the residual phenolic monomer does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for the manufacture of a polyetherimide, comprising:
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a) providing an aromatic bis(ether anhydride) derived from a phenolic monomer that does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors; b) providing a diamine; and c) reacting the aromatic bis(ether anhydride) the diamine under conditions effective to provide a polyetherimide comprising a residual phenolic monomer content less or more than zero and less than 1,000 ppm, wherein the polyetherimide provided in step c) is further characterized in that the residual phenolic monomer does not exhibit a half maximal inhibitory concentration (IC50) less than 0.00025M for alpha or beta in vitro estradiol receptors. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification