SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION
2 Assignments
0 Petitions
Accused Products
Abstract
A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
22 Citations
135 Claims
-
1-114. -114. (canceled)
-
115. A method for reducing intraocular pressure in an eye of a subject in need thereof, the method comprising:
-
implanting a first lacrimal implant through a first punctum and into a first lacrimal canaliculus of the eye of the subject, the first lacrimal implant being configured to release a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent to the eye of the patient on a sustained basis; implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the same eye of the subject, the second lacrimal implant being configured to release the intraocular pressure-reducing therapeutic agent to the eye of the patent on a sustained basis; and releasing, on a sustained basis over a selected time course to the eye, a total amount of the intraocular pressure-reducing therapeutic agent from a combination of the first lacrimal implant and the second lacrimal implant, wherein said total amount is sufficient to reduce the intraocular pressure. - View Dependent Claims (116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127)
-
-
128. A method for reducing intraocular pressure in an eye of a subject in need thereof wherein both an upper punctum and a lower punctum of a same eye each have a lacrimal implant inserted into a lacrimal canaliculus and wherein the lacrimal implants are formulated to release, on a sustained basis, an intraocular pressure-reducing therapeutic agent, the method comprising:
-
implanting a first lacrimal implant through a first punctum and into a first lacrimal canaliculus of the eye of the subject, the first lacrimal implant being configured to release a therapeutically effective amount of latanoprost, the intraocular pressure-reducing therapeutic agent, to the eye of the patient on a sustained basis; implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the same eye of the subject, the second lacrimal implant being configured to release a therapeutically effective amount of latanoprost to the eye of the patent on a sustained basis; and releasing, on a sustained basis over about at least four weeks to the eye, a total amount of the intraocular pressure-reducing therapeutic agent from a combination of the first lacrimal implant and the second lacrimal implant, wherein said total amount is sufficient to reduce the intraocular pressure of the eye by at least 5 mm Hg from baseline for a continuous period of about 4 weeks. - View Dependent Claims (129, 130, 131, 132, 133, 134, 135)
-
Specification