NUTRITIONAL COMPOSITIONS CONTAINING HUMAN MILK OLIGOSACCHARIDES AND METHODS FOR USING THE SAME

• US 20130059815A1
• Filed: 09/06/2012
• Published: 03/07/2013
• Est. Priority Date: 12/02/2008
• Status: Abandoned Application

• Current Assignee: Prolacta Bioscience Inc.
• Original Assignee: Prolacta Bioscience Inc.
• Inventors: Eaker, Scott, Rechtman, David J., FOURNELL, Joseph, Elster, Scott
• Application Number:
  US13/605,223
• Publication Number:
  US 20130059815A1
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A23C 3/02 by heating A23C3/07 takes precedence
• CPC Class Codes: A23C 9/1422 by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate
• CPC Class Codes: A23C 9/1427 by dialysis, reverse osmosis or hyperfiltration, e.g. for concentrating or desalting
• CPC Class Codes: A23C 9/148 by molecular sieve or gel filtration or chromatographic treatment A23C9/1465 takes precedence
• CPC Class Codes: A23C 9/1522 Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
• CPC Class Codes: A23C 9/158 containing vitamins or antibiotics
• CPC Class Codes: A23C 9/206 Colostrum; Human milk
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals

Abstract

This disclosure features human milk permeates and compositions containing the same obtained from fractionated whole human milk. The oligosaccharide rich permeate and permeate compositions of the present invention are useful as nutritional supplements for pre-term and full term infants, for establishing or maintaining gut flora and for treating the symptoms of inflammatory bowel disease.

Claims

1-63. -63. (canceled)

64. A nutritional supplement comprising human milk oligosaccharides.

65. The nutritional supplement of claim 64, wherein said nutritional supplement is administered as a part of a non-human milk baby formula.

66. The nutritional supplement of claim 64 wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides.

67. The nutritional supplement of claim 66 wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose.

68. The nutritional supplement of claim 64 wherein said human milk oligosaccharides are fucosilated and/or sialilated.

69. The nutritional supplement of claim 64 further comprising vitamins and/or minerals.

70. The nutritional supplement of claim 64 further comprising a probiotic.

71. The nutritional supplement of claim 70 wherein the probiotic is a lactobacilli and/or a bifidobacteria.

72. The nutritional supplement of claim 71 wherein the probiotic is a bifidobacteria.

97. The nutritional supplement of claim 64, wherein the human milk oligosaccharides are derived from human milk.

73. A method for promoting the development of beneficial gut flora in preterm infants or neonates or maintaining proper gut flora in children and adults comprising administering a nutritional supplement comprising human milk oligosaccharides.

74. The method of claim 73 wherein said nutritional supplement is added to a human milk formulation or a non-human milk formulation prior to administration.

75. The method of claim 74, wherein said nutritional supplement is added to a non-human milk formulation prior to administration.

76. The method of claim 73 wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides.

77. The method of claim 76 wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose.

78. The method of claim 73 wherein said human milk oligosaccharides are fucosilated and/or sialilated.

79. The method of claim 73 further comprising vitamins and/or minerals.

80. The method of claim 73 further comprising a probiotic.

81. The method of claim 80 wherein the probiotic is a lactobacilli and/or a bifidobacteria.

82. The method of claim 81 wherein the probiotic is a bifidobacteria.

98. The method of claim 73, wherein the human milk oligosaccharides are derived from human milk.

83. A method for treating an inflammatory bowel disease comprising administering a nutritional supplement comprising human milk oligosaccharides.

84. The method of claim 83 wherein the inflammatory bowel disease is selected from the group consisting of ulcerative colitis, indeterminate colitis, microscopic colitis, collagenous colitis, Crohn'"'"'s disease, and irritable bowel disease.

85. The method of claim 83 wherein the nutritional supplement is administered to a preterm infant, infant, child or adult.

86. The method of claim 83 wherein said nutritional supplement is added to a human milk formulation or a non-human milk formulation prior to administration.

87. The method of claim 86, wherein said nutritional supplement is added to a non-human milk formulation prior to administration.

88. The method of claim 87 wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides.

89. The method of claim 88 wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose.

90. The nutritional supplement of claim 83 wherein said human milk oligosaccharides are fucosilated and/or sialilated.

99. The method of claim 83, wherein the human milk oligosaccharides are derived from human milk.

91. A method of treating or preventing necrotizing Enterocolitis comprising administering a nutritional composition comprising human milk oligosaccharides.

92. The method of claim 91 wherein said nutritional supplement is added to a human milk formulation or a non-human milk formulation prior to administration.

93. The method of claim 92, wherein said nutritional supplement is added to a non-human milk formulation prior to administration.

94. The method of claim 91 wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides.

95. The method of claim 94 wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose.

96. The method of claim 91 wherein said human milk oligosaccharides are fucosilated and/or sialilated.

100. The method of claim 91, wherein the human milk oligosaccharides are derived from human milk.