FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE
First Claim
1. A bispecific antibody comprising at least two fab fragments, wherein the first fab fragment comprises at least one antigen binding site specific for a first antigen;
- and the second fab fragment comprises at least one antigen binding site specific for a second antigen wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and
wherein the bispecific antibody is devoid of a Fc domain.
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Abstract
The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
57 Citations
14 Claims
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1. A bispecific antibody comprising at least two fab fragments, wherein the first fab fragment comprises at least one antigen binding site specific for a first antigen;
- and the second fab fragment comprises at least one antigen binding site specific for a second antigen wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and
wherein the bispecific antibody is devoid of a Fc domain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- and the second fab fragment comprises at least one antigen binding site specific for a second antigen wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and
Specification