METHOD FOR DATA REDUCTION AND CALIBRATION OF AN OCT-BASED PHYSIOLOGICAL MONITOR
First Claim
1. A method for generating calibrating data for an optical coherence tomography (OCT) device, the method comprising:
- computing intensity differences between at least two OCT scans of biological tissue to generate an intensity difference plot;
selecting, based on the intensity difference plot, portions of the at least two OCT scans correlating with at least two blood analyte measurements, the at least two blood analyte measurements obtained independently from the at least two OCT scans; and
generating, using a processor, calibration data for an OCT device based in part on the selected portions of the OCT scans.
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Abstract
The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.
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Citations
22 Claims
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1. A method for generating calibrating data for an optical coherence tomography (OCT) device, the method comprising:
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computing intensity differences between at least two OCT scans of biological tissue to generate an intensity difference plot; selecting, based on the intensity difference plot, portions of the at least two OCT scans correlating with at least two blood analyte measurements, the at least two blood analyte measurements obtained independently from the at least two OCT scans; and generating, using a processor, calibration data for an OCT device based in part on the selected portions of the OCT scans. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. Non-transitory computer-readable storage having stored thereon instructions that, when executed, direct a computing system to perform operations comprising:
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computing intensity differences between at least two OCT scans of biological tissue to generate an intensity difference plot; selecting, based on the intensity difference plot, a portion of the at least two OCT scans correlating with at least two blood analyte measurements, the at least two blood analyte measurements obtained independently from the at least two OCT scans; and generating calibration data for an OCT device using the selected portions of the OCT scans. - View Dependent Claims (11, 12, 13)
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14. An apparatus generating calibrating data for an optical coherence tomography (OCT) device, the apparatus comprising:
a processor configured to; select at least two OCT scans from a plurality of OCT scans based in part on at least two blood analyte measurements, the at least two blood analyte measurements obtained independently from the at least two OCT scans; compute intensity differences between the at least two OCT scans of biological tissue; and generate, using a processor, calibration data for an OCT device based in part on the computed intensity differences between the at least two OCT scans. - View Dependent Claims (15, 16, 17)
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18. A method for generating calibrating data for an optical coherence tomography (OCT) device, comprising:
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identifying at least one discontinuity in data associated with OCT scans of biological tissue; selecting, based on the at least one discontinuity, portions of each of the OCT scans correlating with blood analyte measurements obtained independently from the OCT scans; and determining, using a processor, calibration data for an OCT device using the selected portions of the OCT scans. - View Dependent Claims (19, 20, 21, 22)
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Specification