Systems, devices, and methods including implants for managing cumulative x-ray radiation dosage

• US 20130064348A1
• Filed: 09/08/2011
• Published: 03/14/2013
• Est. Priority Date: 09/08/2011
• Status: Active Grant

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Smith, Michael A., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Granted Patent: US 8,666,022 B2
• Time in Patent Office: Days
• US Class Current: 378/65
• CPC Class Codes: A61N 5/1038 taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1071 for verifying the dose delivered by the treatment plan
• CPC Class Codes: G01T 1/02 Dosimeters G01T1/15 takes precedence
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00

Abstract

Systems, devices, and methods are described including implantable radiation sensing devices having exposure determination devices that determines cumulative exposure information based on the at least one in vivo measurand.

Claims

1-103. -103. (canceled)

104. An implantable radiation sensing device, comprising:

a proposed dose verification device configured to transcutaneously elicit proposed dose information from an external x-ray radiation-emitting system; and

an exposure determination device configured to determine a potential exposure status associated with the proposed dose information from the external x-ray radiation-emitting system and to generated potential exposure status information.

105. The implantable radiation sensing device of claim 104, further comprising:

a biocompatible housing enclosing the proposed dose verification device and the exposure determination device.

106. The implantable radiation sensing device of claim 104, wherein the proposed dose verification device includes a transceiver operable to concurrently or sequentially transmit or receive one or more of proposed dose information or potential exposure status information.

109. The implantable radiation sensing device of claim 104, wherein the proposed dose verification device includes a transceiver operable to communicate an authorization status to the external x-ray radiation-emitting system.

110. The implantable radiation sensing device of claim 104, wherein the proposed dose verification device includes a transceiver operable to communicate potential exposure status information to the external x-ray radiation-emitting system.

111. The implantable radiation sensing device of claim 104, wherein the proposed dose verification device includes an irradiation authorization component that communicates an authorization status to the external x-ray radiation-emitting system.

113. The implantable radiation sensing device of claim 104, wherein the proposed dose verification device includes an irradiation authorization component that generates one or more cryptographic keys, based on potential exposure status information, that provides authorization to the external x-ray radiation-emitting system to initiate x-ray radiation delivery.

115. The implantable radiation sensing device of claim 104, wherein the proposed dose verification device includes a transceiver operable to communicate modified dose data to the external x-ray radiation-emitting system.

118. The implantable radiation sensing device of claim 104, further comprising:

a user identification circuit operable to initiate an identification protocol that identifies one of the implantable radiation sensing device or the external x-ray radiation-emitting system and initiates a data transmission protocol between the implantable radiation sensing device and the external x-ray radiation-emitting system based on the identification protocol.

123. The implantable radiation sensing device of claim 104, the proposed dose verification device further comprising:

an x-ray radiation sensor device including one or more pixels that acquire at least a portion of a transcutaneous x-ray radiation stimulus emitted by the external x-ray radiation-emitting system and transduce the x-ray radiation stimulus acquired by the x-ray radiation sensor device into at least one measurand indicative of an x-ray radiation exposure during an integration period of the x-ray radiation sensor device.

124. The implantable radiation sensing device of claim 104, wherein the exposure determination device includes one or more memory devices having radiation exposure information stored thereon and a computing device that compares the proposed dose information from the external x-ray radiation-emitting system to the radiation exposure information, and generates at least one of proposed absorbed dose data, proposed absorbed dose rate data, proposed committed effective dose data, proposed cumulative dose data, proposed effective dose data, proposed equivalent dose data, or proposed exposure data based on the comparison.

130. The implantable radiation sensing device of claim 104, further comprising:

an interrogation-selective interface operably coupled to the exposure determination device, the interrogation-selective interface operable to provide cumulative potential exposure status information in response to at least one of electromagnetic interrogation or acoustic interrogation of the interrogation-selective interface that satisfies interrogation-selective criteria.

107. (canceled)

108. (canceled)

112. (canceled)

114. (canceled)

116. (canceled)

117. (canceled)

119-122. -122. (canceled)

125-129. -129. (canceled)

131-135. -135. (canceled)

136. A method, comprising:

receiving potential x-ray exposure event information associated with an x-ray radiation-emitting system via an indwelling x-ray radiation sensing transponder; and

determining a potential exposure status of a user based on a comparison of the x-ray exposure event information to reference cumulative exposure information.

139. The method of claim 136, further comprising:

storing the potential x-ray exposure event information on one or more memories carried by the indwelling x-ray radiation sensing transponder.

140. The method of claim 136, further comprising:

generating a response based on the potential exposure status.

142. The method of claim 140, where generating the response includes providing a radiation exposure status.

143. The method of claim 140, wherein generating the response includes generating at least one of a visual representation, an audio representation, a haptic representation, or a tactile representation indicative of the potential exposure status.

144. The method of claim 136, further comprising:

detecting at least a portion of a transcutaneously received x-ray radiation stimulus via the indwelling x-ray radiation sensing transponder; and

determining an actual exposure status based on the detected transcutaneously received x-ray radiation stimulus.

146. The method of claim 144, further comprising:

updating cumulative exposure information based on the actual exposure status.

137. (canceled)

138. (canceled)

141. (canceled)

145. (canceled)

147. (canceled)

148. A method, comprising:

eliciting proposed dose information from an x-ray radiation-emitting system via an indwelling x-ray radiation sensing device; and

determining a potential exposure status of a user in response to one or more transcutaneously received signals associated with the elicited proposed dose information.

151. The method of claim 148, further comprising:

generating at least one of a visual representation, an audio representation, a haptic representation, or a tactile representation indicative of the potential exposure status of the user.

152. The method of claim 148, further comprising:

updating a stored radiation treatment protocol based on the potential exposure status of the user.

153. The method of claim 148, further comprising:

determining an actual exposure status of the user based on a comparison of an in vivo detected x-ray radiation measurand from the indwelling implant to the proposed dose information.

155. The method of claim 153, further comprising:

generating at least one of a visual representation, an audio representation, a haptic representation, or a tactile representation indicative of the actual exposure status of the user.

156. The method of claim 153, further comprising:

updating cumulative exposure information based on the actual exposure status.

157. The method of claim 153, further comprising:

modifying a user-specific radiation treatment regimen based on the actual exposure status of the user.

158. The method of claim 153, further comprising:

initiating a radiation treatment protocol based on the actual exposure status of the user.

149. (canceled)

150. (canceled)

154. (canceled)