INDUCING APOPTOSIS IN QUIESCENT CELLS
First Claim
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1. A composition comprising an autophagy inhibitor and at least one of an NADPH modulator or a glutathione modulator.
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Abstract
Compositions comprising an autophagy inhibitor and at least one of an NADPH modulator or a glutathione inhibitor are provided. Methods of inhibiting or killing a quiescent cell are provided. Methods of treating cancer are provided. Methods of identifying compositions that inhibit or kill quiescent cells are provided. Methods of identifying compositions that inhibit or kill quiescent cells are provided. Methods of inducing apoptosis are provided. Methods of sensitizing quiescent cells to proteasome inhibitors are provided.
8 Citations
40 Claims
- 1. A composition comprising an autophagy inhibitor and at least one of an NADPH modulator or a glutathione modulator.
- 16. A method of inhibiting or killing a quiescent cell comprising exposing the quiescent cell to at an autophagy inhibitor and at least one of an NADPH modulator or a glutathione modulator.
- 21. A method of treating cancer comprising administering an autophagy inhibitor and at least one of an NADPH modulator or a glutathione modulator to a cancer patient.
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28. A method of identifying compositions that inhibit or kill quiescent cells comprising:
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identifying a target by analyzing at least one of the metabolic flux, gene expression, protein expression, mircoRNA content, histone modification, signaling pathway activity, or physiology of quiescent cells; identifying a candidate inhibitor of the target; and exposing a quiescent cell to the candidate inhibitor and identifying whether the candidate inhibitor inhibits or kills the quiescent cell. - View Dependent Claims (29, 30)
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- 31. A method of identifying compositions that inhibit or kill quiescent cells comprising exposing a quiescent cell to at least one candidate inhibitor and monitoring the physiology of the quiescent cell.
- 34. A method of inducing apoptosis comprising exposing at least one of a cell, a cell culture, a tissue, an organ, an organism or a human to a composition comprising an autophagy inhibitor and at least one of an NADPH modulator or a glutathione modulator.
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37. A method of sensitizing quiescent cells to proteasome inhibitors comprising exposing a cell, a cell culture, a tissue, an organ, an organism or a human to an autophagy inhibitor and at least one of an NADPH modulator or a glutathione modulator.
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38. A composition comprising DHEA and an autophagy inhibitor.
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39. A method of inhibiting or killing a quiescent cell comprising exposing the quiescent cell to DHEA and an autophagy inhibitor.
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40. A method of treating cancer comprising administering DHEA and an autophagy inhibitor to a cancer patient.
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