ENZYME-LOGIC BIOSENSING
First Claim
1. A biochemical logic sensing system, comprising:
- a network of enzyme-biocatalyzed logic gates adapted to receive biomarker inputs and perform an enzyme-biocatalyzed reaction resembling a Boolean logic operation using the received biomarker inputs to generate an output of the enzyme-biocatalyzed reaction; and
a signal processing unit connected to the network of enzyme-biocatalyzed logic gates, the signal processing unit to process the generated output of the enzyme-biocatalyzed reaction and generate a digital binary output having a value of zero or one,wherein the generated digital binary output indicates an injury.
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Abstract
Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme-biocatalyzed logic gates adapted to receive biomarker input signals and perform an enzyme-biocatalyzed reaction resembling a Boolean logic operation using the received biomarker input signals to generate an output signal of the enzyme-biocatalyzed reaction. A signal processing unit is connected to the network of enzyme-biocatalyzed logic gates. The signal processing unit processes the generated output signal of the enzyme-biocatalyzed reaction and generates a digital binary output having a value of zero or one. The generated digital binary output indicates a type of an injury.
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Citations
53 Claims
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1. A biochemical logic sensing system, comprising:
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a network of enzyme-biocatalyzed logic gates adapted to receive biomarker inputs and perform an enzyme-biocatalyzed reaction resembling a Boolean logic operation using the received biomarker inputs to generate an output of the enzyme-biocatalyzed reaction; and a signal processing unit connected to the network of enzyme-biocatalyzed logic gates, the signal processing unit to process the generated output of the enzyme-biocatalyzed reaction and generate a digital binary output having a value of zero or one, wherein the generated digital binary output indicates an injury. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 48, 49, 50, 51, 52, 53)
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46. A method of detecting a medical condition using a biochemical sensing system comprising:
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operating a network of enzyme-biocatalyzed logic gates in a biochemical sensing system to perform an enzyme-biocatalyzed reaction resembling a Boolean logic operation on biomarker inputs to generate an output of the enzyme-biocatalyzed reaction; operating a signal processing unit in the biochemical sensing system to generate a digital binary output based on the generated output of the enzyme-biocatalyzed reaction, wherein the digital binary output indicates presence or absence of a medical condition. - View Dependent Claims (47)
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Specification