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METHOD AND APPARATUS FOR PREPARING NOVEL LIPOSOME

  • US 20130069261A1
  • Filed: 02/24/2011
  • Published: 03/21/2013
  • Est. Priority Date: 02/24/2010
  • Status: Active Grant
First Claim
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1. A method for preparing liposome formulation, the method comprising the steps of:

  • (a) dissolving a lipid fraction comprising at least one kind selected from phospholipid and sterol, and a bioactive substance in an organic solvent;

    (b) putting an organic solvent solution of the step (a) together with a saccharide carrier into a reaction vessel, and introducing a supercritical fluid thereto so as to prepare proliposome particles coated with a lipid-bioactive substance mixture;

    (c) discharging the supercritical fluid in step (b) by compression so as to obtain the proliposome particles; and

    (d) hydrating the proliposome particles in step (c) by an aqueous solution comprising water so as to form a liposome solution.

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