Drug Delivery Systems and Applications
First Claim
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1. A medical material comprisinga biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a low water soluble lipophilic compound and further comprise a therapeutic agent that comprises a protein having a secondary and/or a tertiary structure, wherein the lipophilic particles are solid at 20°
- C. and have a low water solubility in physiological saline at physiological temperature, with the protein being released from the microparticles and the medical material in a conformation that is substantially free of denaturation as measurable by enzyme-linked immunosorbent assay and isoelectric focusing.
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Abstract
Certain embodiments of the invention include medical materials and methods comprising a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a therapeutic agent, wherein the lipophilic particles have a low water solubility in physiological saline at physiological temperature.
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Citations
49 Claims
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1. A medical material comprising
a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a low water soluble lipophilic compound and further comprise a therapeutic agent that comprises a protein having a secondary and/or a tertiary structure, wherein the lipophilic particles are solid at 20° - C. and have a low water solubility in physiological saline at physiological temperature, with the protein being released from the microparticles and the medical material in a conformation that is substantially free of denaturation as measurable by enzyme-linked immunosorbent assay and isoelectric focusing.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A process of making a medical material comprising
coating a protein powder with a low water soluble lipophilic compound to make particles, dispersing the particles in a medical hydrogel implant, with the protein having a secondary and/or a tertiary structure and being released from the microparticles and the medical material in a conformation that is substantially free of denaturation as measurable by enzyme-linked immunosorbent assay and isoelectric focusing.
- 36. A method of delivering a therapeutic agent to a patient comprising placing a hydrogel in a patient that comprises a collection of particles that comprise a low water soluble lipophilic compound and a therapeutic agent, with the agent being released into the patient.
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43. A kit comprising an applicator, a hydrogel precursor, and lipophilic particles that comprise a low water soluble lipophilic compound and a therapeutic agent, wherein the lipophilic particles are solid at 20°
- C. and have a low water solubility in physiological saline at physiological temperature, with the applicator being adapted to deliver a mixture of the particles and the precursor into an eye.
- View Dependent Claims (44, 45, 46, 47, 48, 49)
Specification