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Drug Delivery Systems and Applications

  • US 20130071462A1
  • Filed: 09/16/2011
  • Published: 03/21/2013
  • Est. Priority Date: 09/16/2011
  • Status: Active Grant
First Claim
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1. A medical material comprisinga biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a low water soluble lipophilic compound and further comprise a therapeutic agent that comprises a protein having a secondary and/or a tertiary structure, wherein the lipophilic particles are solid at 20°

  • C. and have a low water solubility in physiological saline at physiological temperature, with the protein being released from the microparticles and the medical material in a conformation that is substantially free of denaturation as measurable by enzyme-linked immunosorbent assay and isoelectric focusing.

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