THERANOSTIC AND DIAGNOSTIC METHODS USING SPARC AND HSP90
First Claim
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1. A method of selecting one or more candidate treatment for a malignancy in a subject comprising:
- (a) obtaining a sample of the malignancy;
(b) detecting a level of SPARC and HSP90 in the sample; and
(c) selecting one or more treatment associated with SPARC and HSP90 if the sample has an elevated level of SPARC and HSP90 as compared to a reference., thereby selecting the one or more candidate treatment.
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. The molecular profiling can be used to provide a diagnosis, prognosis, or theranosis for the disease, such as identifying a candidate treatment. The methods can detect overexpression of SPARC and HSP90. The cancer can be, e.g., a renal cell carcinoma or an interdigitating dendritic cell sarcoma.
4 Citations
32 Claims
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1. A method of selecting one or more candidate treatment for a malignancy in a subject comprising:
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(a) obtaining a sample of the malignancy; (b) detecting a level of SPARC and HSP90 in the sample; and (c) selecting one or more treatment associated with SPARC and HSP90 if the sample has an elevated level of SPARC and HSP90 as compared to a reference., thereby selecting the one or more candidate treatment. - View Dependent Claims (2, 3, 4, 5, 12, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 26, 28, 29, 30, 31)
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6-11. -11. (canceled)
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13. (canceled)
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22. (canceled)
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25. (canceled)
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27. (canceled)
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32-53. -53. (canceled)
Specification