MODULATION OF SIRTUINS BY VAGUS NERVE STIMULATION
First Claim
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1. A method of modulating SIRT activity and/or level in a patient, the method comprising modulating SIRT activity and/or level by applying stimulation to a subject'"'"'s vagus nerve from an implanted micro stimulator.
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Abstract
Systems, devices and methods for modulation of sirtuins by neurostimulation. In particular, sirtuins may be modulated by stimulation of the vagus nerve. Further described herein generally are methods, systems and devices, for specifically modulating sirtuins, including sub-sets (types or localized regions) of sirtuins by vagus nerve stimulation (VNS).
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Citations
29 Claims
- 1. A method of modulating SIRT activity and/or level in a patient, the method comprising modulating SIRT activity and/or level by applying stimulation to a subject'"'"'s vagus nerve from an implanted micro stimulator.
- 10. A method of treating a disorder by modulating SIRT activity and/or level in a patient, the method comprising modulating SIRT activity and/or level by applying stimulation from a stimulator to stimulate the vagus nerve.
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26. A system for treating a disorder in a patient buy modulating SIRT, the system comprising:
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a stimulator configured to apply a low duty-cycle stimulation to a vagus nerve; and a controller configured to set a dose for the stimulator wherein the dose comprises a supra-threshold pulse followed by an off-period of greater than four hours configured to modulate SIRT level and/or activity. - View Dependent Claims (27, 28, 29)
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Specification