Sensor Calibration
First Claim
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1. A method of calibrating a reversible-binding sensor for detecting an analyte, which method comprises:
- varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor;
(ii) determining the sensor output for the first calibration solution as a function of temperature;
(iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution;
(iv) determining the sensor output for the second calibration solution as a function of temperature; and
(v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.
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Abstract
A method of calibrating a reversible-binding sensor for detecting an analyte includes:
- (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor;
- (ii) determining the sensor output for the first calibration solution as a function of temperature;
- (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution;
- (iv) determining the sensor output for the second calibration solution as a function of temperature; and
- (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.
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Citations
22 Claims
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1. A method of calibrating a reversible-binding sensor for detecting an analyte, which method comprises:
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varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A calibration system comprising one or more control modules, wherein the one or more control modules are configured to contact the sensing region of a reversible binding sensor with consecutive calibration solutions;
- monitor or adjust the temperature of the calibration solutions; and
determine sensor output of said sensor as a function of temperature for each of said calibration solutions. - View Dependent Claims (19, 20, 21, 22)
- monitor or adjust the temperature of the calibration solutions; and
Specification