PREPARATION

• US 20130084250A1
• Filed: 11/29/2012
• Published: 04/04/2013
• Est. Priority Date: 06/02/2010
• Status: Active Grant

• Current Assignee: Fluoron GmbH
• Original Assignee: Fluoron GmbH
• Inventors: Hagedorn, Nadine, Rizzo, Stanislao, Rodrigues, Eduardo
• Granted Patent: US 8,865,131 B2
• Time in Patent Office: Days
• US Class Current: 424/10.32
• CPC Class Codes: A61K 47/06 Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/18 Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• CPC Class Codes: A61K 49/0021 the fluorescent group being a small organic molecule
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: C09B 67/0082 in liquid form

Abstract

The invention relates to a dye-containing preparation for use in ophthalmology and retinal surgery.

Claims

1. Preparation for use in ophthalmology or retinal surgery, containing at least one perfluorinated alkane, at least one semifluorinated alkane and at least one colour-giving substance dissolved in the semifluorinated alkane, the semifluorinated alkane being selected from:

R_FR_H or R_FR_HR_F

wherein R_F is a linear or branched perfluoroalkyl group having 3 to 20 carbon atoms and R_H is a linear or branched, saturated alkyl group having 1 to 20 carbon atoms, wherein the total chain length amounts to 4 to 30 carbon atoms and wherein the ratio of the perfluorinated alkane to the semifluorinated alkane, relative to volume, amounts to 95;

5 to 5;

95.

2. Preparation according to claim 1, characterised in that the colour-giving substance is a solvent dye or fat dye.

3. Preparation according to claim 1, characterised in that the dye is a solvent dye that has been selected from the group consisting of:

Solvent Blue 36, Solvent Blue 35, Solvent Green 5, Solvent Violet 13, Solvent Blue 8, Solvent Blue 18, Solvent Blue 63, Solvent Green 3, Solvent Green 7, Solvent Violet 10, Solvent Violet 12, Solvent Violet 26, Solvent Red 27, Solvent Yellow 56, Solvent Green 3, Solvent Yellow 33, Solvent Red 19, Solvent Red 1, Solvent Yellow 16.

4. Preparation according to claim 1, characterised in that the dye is a fat dye that has been selected from the group consisting of:

Sudan I, Sudan II, Sudan III, Sudan IV.

5. Preparation according to claim 1, characterised in that the dye fluoresces.

6. Preparation according to claim 1, characterised in that the dye is contained in the finished preparation in a quantity from 0.08 g/L to 0.001 g/L, more preferably 0.07 g/L to 0.003 g/L, for example 0.06 g/L to 0.006 g/L.

7. Preparation according to claim 1, characterised in that the perfluoroalkane has been selected from the group consisting of C₄F₁₀, C₅F₁₂, C₆F₁₄, C₇F₁₆, C₈F₁₈, C₉F₂₀ and C₁₀F₂₂.

8. Preparation according to claim 1, characterised in that the preparation has a density of more than 1 g/cm³, preferably of more than 1.33 g/cm³, and particularly preferably of more than 1.5 g/cm³.

9. Preparation according to claim 1, characterised in that the quantity of semifluorinated alkane amounts to 5 vol. % to 60 vol. %, preferably 10 vol. % to 40 vol. %, and particularly preferably 10 vol. % to 20 vol. %, relative to the total volume of the preparation.

10. Preparation according to claim 1, in the form of an infusion fluid.

11. Use of a preparation according to claim 1 in ophthalmology or retinal surgery, in particular for vitrectomy or surgical procedures in connection with retinal detachment.

12. Use of a preparation according to one of claim 1 as infusion fluid in retinal surgery.