MONITORING SYSTEM

• US 20130085355A1
• Filed: 09/28/2012
• Published: 04/04/2013
• Est. Priority Date: 09/30/2011
• Status: Abandoned Application

• Current Assignee: University of Limerick
• Original Assignee: University of Limerick
• Inventors: Koball, Sebastian, Ewald, Hartmut, Hinz, Michael V., Andruschenko, Sergej, Kraitl, Jens, Leen, Gabriel, Timm, Ulrich, Lewis, Elfeld, Mcgrath, Deirdre
• Application Number:
  US13/629,766
• Publication Number:
  US 20130085355A1
• Time in Patent Office: Days
• US Class Current: 600/324
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/028 by thermo-dilution
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/6826 Finger

Abstract

A system and method for non-invasive monitoring of cardiac activity in a human or animal is disclosed. A radiation source directs radiation through a patient site, and a detector detects radiation after passing through a patient tissue. A processor processes data derived from the detected radiation, determining pulse peaks and troughs and calculating area under a pulse peak to provide a real time cardiac output indicator. The radiation wavelength is on a haemoglobin spectral isosbestic point, not influenced by changes in SpO2 concentration. The processor performs numerical integration of pulse data between troughs, and wherein said integration is performed per pulse. Preferably, the processor monitors trends, thus providing very useful information and reducing need for calibration.

Claims

1. A system for non-invasive monitoring of cardiac activity in a human or animal, the system comprising:

a radiation source,

a driver for the radiation source,

a radiation detector, and

a processor for processing data derived from the detected radiation, in which the processor is adapted to determine pulse peaks and troughs and to calculate area under a pulse peak to provide a real time cardiac output indicator data.

2. The system as claimed in claim 1, wherein the processor is adapted to perform tracking of a cardiac output trend in addition to or instead of an absolute cardiac output value.

3. The system as claimed in claim 1, wherein the radiation source and the detector are arranged to operate on either the transmissive or the reflectance principles.

4. The system as claimed in claim 1, wherein the system is adapted to acquire a non-invasive signal by irradiating a measuring site with the radiation source operating at a wavelength on a haemoglobin spectral isosbestic point, in which radiation is modulated thereafter by blood circulation activity.

5. The system as claimed in claim 1, wherein the processor is adapted to perform numerical integration of pulse data between troughs, and wherein said integration is performed per pulse.

6. The system as claimed in claim 1, wherein the processor is adapted to convert said indicator data to cardiac output data by usage of a predefined calibration curve based on cardiac output values from a large patient pool.

7. The system as claimed in claim 1, wherein the processor is adapted to perform numerical integration of pulse data between troughs, and wherein said integration is performed per pulse;

and wherein the processor is adapted to integrate by executing an adaptive function.

8. The system as claimed in claim 1, wherein the processor is adapted to calculate cardiac output values correlating with beat volume units based on the terms of a predetermined empirical calibration curve derived from thermodilution measurements of cardiac output.

9. The system as claimed in claim 1, wherein the processor is adapted to calculate cardiac output values based on a predetermined empirical calibration curve derived from thermodilution measurements of cardiac output, to determine beat volume units based on stroke index, and to combine the beat volume units with cardiovascular characteristics of a patient.

10. The system as claimed in claim 1, where the processor is adapted to determine cardiac output measurement data and to calibrate said data using a thermodilution technique.

11. The system as claimed in claim 1, wherein the processor is adapted to execute an autoregulatory compensation algorithm.

12. The system as claimed in claim 1, comprising a plurality of pairs of radiation sources and detectors, and the processor is adapted to process data from said plurality of detectors.

13. The system as claimed in claim 1, comprising a plurality of pairs of radiation sources and detectors, and the processor is adapted to process data from said plurality of detectors and said sensors, and the system further comprises at least one non-optical sensor;

and said non-optical sensor includes at least one ECG sensor.

14. The system as claimed in claim 1, wherein the processor is adapted to estimate haemoglobin content and blood oxygen concentration, and to derive from said estimations an estimate of total oxygen uptake.

15. A method for non-invasive monitoring of cardiac activity in a human or animal, the method comprising:

a radiation source directing radiation through a patient site,

a detector detecting radiation after passing through a patient tissue, and

a processor processing data derived from the detected radiation, in which the processor determines pulse peaks and troughs and calculates area under a pulse peak to provide a real time cardiac output indicator.

16. The method as claimed in claim 15, wherein the processor performs tracking of a cardiac output trend in addition to or instead of an absolute cardiac output value.

17. The method as claimed in claim 15, wherein the radiation source emits radiation with wavelength at haemoglobin or SpO2 spectral isosbestic points, in which radiation is modulated thereafter only by blood circulation activity.

18. The method as claimed in claim 15, wherein the processor performs numerical integration of pulse data between troughs, and wherein said integration is performed per pulse.

19. The method as claimed in claim 15, wherein the processor converts indicator data to beat volume units.

20. The method as claimed in either of claim 15, wherein the processor performs numerical integration of pulse data between troughs;

and wherein the processor integrates by executing an adaptive function.

21. The method as claimed in claim 15, wherein the processor calculates cardiac output values correlating with beat volume units based on the terms of a predetermined empirical calibration curve derived from thermodilution measurements of cardiac output.

22. The method as claimed in claim 15, wherein the processor calculates cardiac output values based upon an equation combining beat volume units with individual cardiovascular characteristics of a patient.

23. The method as claimed in claim 15, wherein the radiation source and the detector are applied at a peripheral patient location.

24. The method as claimed in claim 15, wherein the processor executes an autoregulatory compensation algorithm.

25. A computer readable medium comprising software code adapted to perform, when executed by a digital processor, a method comprising the steps of:

receiving data from a detector which detects radiation after passing through a patient tissue, and

processing data derived from the detected radiation, to determine pulse peaks and troughs and to calculate area under a pulse peak to provide a real time cardiac output indicator.