DEVICE FOR INTERACTING WITH NEUROLOGICAL TISSUE AND METHODS OF MAKING AND USING THE SAME
First Claim
1. An implantable neurological probe comprising:
- an elongated shaft having a distal end and an internal lumen;
a support cylinder slidingly disposed in only a distal portion of the internal lumen;
a plurality of shafts coupled to the support cylinder and arranged to be selectively extended from the distal end of the elongated shaft;
a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer,a stylet removably disposed in the internal lumen and configured to contact the support cylinder to selectively extend the plurality of shafts during implantation; and
a pull wire coupled to the support cylinder to selectively retract the support cylinder and plurality of shafts within the internal lumen.
2 Assignments
0 Petitions
Accused Products
Abstract
Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.
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Citations
46 Claims
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1. An implantable neurological probe comprising:
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an elongated shaft having a distal end and an internal lumen; a support cylinder slidingly disposed in only a distal portion of the internal lumen; a plurality of shafts coupled to the support cylinder and arranged to be selectively extended from the distal end of the elongated shaft; a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer, a stylet removably disposed in the internal lumen and configured to contact the support cylinder to selectively extend the plurality of shafts during implantation; and a pull wire coupled to the support cylinder to selectively retract the support cylinder and plurality of shafts within the internal lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An implantable neurological probe comprising:
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an elongated shaft having a distal end and an internal lumen; a plurality of shafts arranged to be selectively extended from the distal end of the elongated shaft; and a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer, wherein the plurality of shafts define a substantially cylindrical volume when fully extended. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for finding a neurological target comprising:
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implanting a neurological probe within a vicinity of a neurological target site, the neurological probe comprising; an elongated shaft having a distal end and an internal lumen; a support cylinder slidingly disposed in only a distal portion of the internal lumen; a plurality of shafts coupled to the support cylinder and arranged to be selectively extended from the distal end of the elongated shaft; a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer, a stylet removably disposed in the internal lumen and configured to contact the support cylinder to selectively extend the plurality of shafts during implantation; and a pull wire coupled to the support cylinder to selectively retract the support cylinder and plurality of shafts within the internal lumen; retracting the plurality of shafts within the internal lumen before surgical implantation; extending the plurality of shafts in the vicinity of the neurological target site following implantation; recording electrophysiological signals from the neurological target site using at least one of the microelectrode elements on at least one of the protruding shafts; and stimulating the neurological target using at least one of the microelectrode elements on at least one of the plurality of shafts. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
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32. A method for finding a neurological target comprising:
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implanting a neurological probe within a vicinity of a neurological target site, the neurological probe comprising; an elongated shaft having a distal end and an internal lumen; a support cylinder slidingly disposed in only a distal portion of the internal lumen; a plurality of shafts coupled to the support cylinder and arranged to be selectively extended from the distal end of the elongated shaft; a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer, a stylet removably disposed in the internal lumen and configured to contact the support cylinder to selectively extend the plurality of shafts during implantation; and a pull wire coupled to the support cylinder to selectively retract the support cylinder and plurality of shafts within the internal lumen; retracting the plurality of shafts within the internal lumen before surgical implantation; expanding the plurality of shafts in the vicinity of the neurological target site following implantation; applying an oscillating electric current between at least two of the microelectrode elements on at least one of the plurality of shafts; detecting an electric voltage between at least two of the microelectrode elements on at least one of the plurality of shafts. - View Dependent Claims (33, 34, 35, 46)
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36. A method for finding a neurological target comprising:
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implanting a neurological probe within a vicinity of a neurological target site, the neurological probe comprising; an elongated shaft having a distal end and an internal lumen; a plurality of shafts arranged to be selectively extended from the distal end of the elongated shaft; and a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer, wherein the plurality of shafts define a substantially cylindrical volume when fully extended. retracting the plurality of shafts within the internal lumen before surgical implantation; extending the plurality of shafts in the vicinity of the neurological target site following implantation; recording electrophysiological signals from the neurological target site using at least one of the microelectrode elements on at least one of the protruding shafts; and stimulating the neurological target using at least one of the microelectrode elements on at least one of the plurality of shafts. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43)
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44. A method for finding a neurological target comprising:
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implanting a neurological probe within a vicinity of a neurological target site, the neurological probe comprising; an elongated shaft having a distal end and an internal lumen; a plurality of shafts arranged to be selectively extended from the distal end of the elongated shaft; and a plurality of microelectrode elements disposed on each of the plurality of shafts, the microelectrode elements comprising a planar substrate having an insulative layer and a plurality of conductive traces disposed on the insulative layer, wherein the plurality of shafts define a substantially cylindrical volume when fully extended; retracting the plurality of shafts within the internal lumen before surgical implantation; expanding the plurality of shafts in the vicinity of the neurological target site following implantation; applying an oscillating electric current between at least two of the microelectrode elements on at least one of the plurality of shafts; detecting an electric voltage between at least two of the microelectrode elements on at least one of the plurality of shafts. - View Dependent Claims (45)
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Specification