ELECTRODE STRUCTURES AND METHODS FOR THEIR USE IN CARDIOVASCULAR REFLEX CONTROL
First Claim
1. A baroreflex modification system comprising:
- a baroreceptor activation device arranged to be coupled to a vascular wall, the vascular wall containing at least one baroreceptor; and
a control system comprising a driver coupled to the baroreceptor activation device, the driver being configured to drive mechanical motion of at least a portion of the activation device, wherein the mechanical motion causes indirect activation of the baroreceptor by stretching or deforming the vascular wall surrounding the baroreceptor.
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Abstract
Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
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Citations
31 Claims
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1. A baroreflex modification system comprising:
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a baroreceptor activation device arranged to be coupled to a vascular wall, the vascular wall containing at least one baroreceptor; and a control system comprising a driver coupled to the baroreceptor activation device, the driver being configured to drive mechanical motion of at least a portion of the activation device, wherein the mechanical motion causes indirect activation of the baroreceptor by stretching or deforming the vascular wall surrounding the baroreceptor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 30, 31)
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28. An implantable baroreflex modification system, comprising:
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a baroreceptor activation device arranged to be coupled to a vascular wall, the vascular wall containing at least one baroreceptor, wherein the activation device includes a means for mechanically activating the baroreceptor; and a control system coupled to the baroreceptor activation device, the control system programmed to deliver a control signal to the baroreceptor activation device to cause the means for mechanically activating to stretch or deform the vascular wall surrounding the baroreceptor.
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29. A method, comprising:
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causing a baroreceptor activation device to be manufactured and made available to a user; causing a control system to be manufactured and made available to the user, the control system comprising a driver coupled to the baroreceptor activation device; and providing instructions to the user, comprising; implanting the baroreceptor activation device in contact with a vascular wall, the vascular wall containing at least one baroreceptor; and causing the driver to drive mechanical motion of at least a portion of the activation device, wherein the mechanical motion causes indirect activation of the baroreceptor by stretching or deforming the vascular wall surrounding the baroreceptor.
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Specification