METAL-ORGANIC FRAMEWORKS WITH EXCEPTIONALLY LARGE PORE APERATURES

• US 20130096210A1
• Filed: 10/12/2012
• Published: 04/18/2013
• Est. Priority Date: 10/13/2011
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Deng, Hexiang, Yaghi, Omar M., Furukawa, Hiroyasu
• Granted Patent: US 9,078,922 B2
• Time in Patent Office: Days
• US Class Current: 514/784
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: B01D 2253/204 Metal organic frameworks (MOF's)
• CPC Class Codes: B01D 53/02 by adsorption, e.g. preparative gas chromatography solid sorbent compositions B01J20/00, preparation of inorganic compounds or elements C01
• CPC Class Codes: B01J 20/0225 Compounds of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt
• CPC Class Codes: B01J 20/226 Coordination polymers, e.g. metal-organic frameworks [MOF], zeolitic imidazolate frameworks [ZIF] preparation of metal complexes containing carboxylic acid moieties C07C51/418; MOF's per se C07F
• CPC Class Codes: B01J 20/28016 Particle form
• CPC Class Codes: B01J 20/28066 being more than 1000 m2/g
• CPC Class Codes: B01J 20/28073 being in the range 0.5-1.0 ml/g
• CPC Class Codes: B01J 20/28076 being more than 1.0 ml/g
• CPC Class Codes: B01J 2220/58 Use in a single column
• CPC Class Codes: C02F 1/285 using synthetic organic sorbents
• CPC Class Codes: C07F 3/02 Magnesium compounds
• CPC Class Codes: C07F 3/06 Zinc compounds
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds
• CPC Class Codes: C07F 7/2224 Compounds having one or more tin-oxygen linkages
• CPC Class Codes: C07K 14/435 from animals; from humans

Abstract

The disclosure relates to metal organic frameworks or isoreticular metal organic frameworks, methods of production thereof, and methods of use thereof.

Claims

1. A MOF or IRMOF comprising the general structure M-L-M, wherein M comprises a metal and L is a linking moiety of Formula I:

2. The MOF or IRMOF of claim 1, wherein M is either a transition metal or an alkaline earth metal.

3. The MOF or IRMOF of claim 1, wherein M is either Mg or Zn.

4. The MOF or IRMOF of claim 3, wherein X¹ and X² are carboxylic acids.

5. The MOF or IRMOF of claim 4, wherein A¹-A⁸ are C.

6. The MOF or IRMOF of claim 5, wherein

R¹ to R¹⁶ are hydroxyls;

R²-R⁵, R⁷, R⁹, R¹¹ and R¹² are hydrogen; and

R⁶ and R⁸ are selected from the group consisting of (C₁-C₁₂)alkyl, (C₁-C₁₂)alkenyl, substituted (C₁-C₁₂)alkenyl, (C₁-C₁₂)alkynyl, substituted (C₁-C₁₂)alkynyl, hetero-(C₁-C₁₂)alkyl, substituted hetero-(C₁-C₁₂)alkyl, hetero-(C₁-C₁₂)alkenyl, substituted hetero-(C₁-C₁₂)alkenyl, hetero-(C₁-C₁₂)alkynyl, and substituted hetero-(C₁-C₁₂)alkynyl.

7. The MOF or IRMOF of claim 6, wherein

R⁶ and R⁸ are (C₁-C₆)alkyls.

8. The MOF or IRMOF of claim 7, wherein z is a number from 1 to 15.

9. The MOF or IRMOF of claim 1, wherein the MOF or IRMOF further comprises a post-framework reactant.

10. The MOF or IRMOF of claim 9, wherein the post-framework reactant decreases the hydrophobicity of the framework.

11. The MOF or IRMOF of claim 1, wherein at least one linking moiety comprises Formula I(a):

13. The MOF or IRMOF of claim 1, further comprising at least one linking moiety having Formula IV(a):

15. The MOF or IRMOF of claim 1, further comprising at least one linking moiety having Formula IV(b):

16. A method of making the MOF or IRMOF of claim 1, comprising a reaction at an elevated temperature comprising a solvent, metal containing salt, and a linking moiety of Formula I:

17. A method of sorption of one or more chemicals from a solution, mixture, or suspension, comprising contacting the chemical with a MOF or IRMOF of claim 1.

18. The method of claim 16 wherein the chemical is an organic molecule.

19. The method of claim 16 wherein the chemical is an inorganic molecule.

20. The method of claim 17, wherein the MOF or IRMOF is disposed within a device.

21. The method of claim 20, wherein the device is a column.

22. A MOF or IRMOF separation system for separating one or more chemicals from a multi-chemical solution, mixture, or suspension, comprising a flow chamber comprising an inlet and an outlet and a MOF or IRMOF of claim 1 disposed within the flow chamber between the inlet and outlet.

23. A MOF or IRMOF drug delivery device comprising a MOF or IRMOF of claim 1 and a pharmaceutically active agent.

12. A MOF or IRMOF comprising the general structure M-L-M, wherein M comprises a metal and L is a linking moiety, and wherein at least one linking moiety comprises Formula IV(a):

14. A MOF or IRMOF comprising the general structure M-L-M, wherein M comprises a metal and L is a linking moiety, and wherein at least one linking moiety comprises Formula IV(b):