SENSING AND SENSORS

• US 20130098780A1
• Filed: 01/28/2011
• Published: 04/25/2013
• Est. Priority Date: 02/03/2010
• Status: Abandoned Application

• Current Assignee: DNA Electronics Limited (Genting Malaysia Berhad)
• Original Assignee: DNA Electronics Limited (Genting Malaysia Berhad)
• Inventors: Georgiou, Pantelis, Prodromakis, Themistoklis, Toumazou, Christofer, Constandinou, Timothy G.
• Application Number:
  US13/576,561
• Publication Number:
  US 20130098780A1
• Time in Patent Office: Days
• US Class Current: 205/792
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 27/4163 checking the operation of, or calibrating, the measuring apparatus G01N27/3274, G01N27/4175 and G01N33/0006 take precedence
• CPC Class Codes: G01N 33/4836 using multielectrode arrays

Abstract

A sensor system comprising a substrate and integrated onto the substrate an array (7) of sensor elements (1), each sensor element comprising one or more inductors (3), one or more electrochemical sensors (4), and one or more optical sensors (2). The system further comprising a controller configured in use to separately address each of the sensor elements (1) to drive the respective inductors and receive outputs of the respective sensors.

Claims

1. A sensor system comprising a substrate and, integrated onto the substrate, a sensor element, the sensor element comprising one or more inductors, one or more electrochemical sensors, and one or more optical sensors, the sensor system further comprising a controller configured in use to drive the one or more inductors and to monitor outputs of the sensors in order to provide a sensor element result.

2. A sensor system according to claim 1 and comprising an array of said sensor elements, said controller being configured in user to separately drive the inductors and monitor the sensors of each sensor element.

3. A sensor system according to claim 1, wherein the sensor elements are fabricated using a CMOS process.

4. A sensor system according to claim 1, wherein the one or more inductors are microcoils.

5. A sensor system according to claim 4, wherein the sensors of each sensor element are located substantially within each associated inductor microcoil.

6. A sensor system according to claim 1, further comprising a structure defining channels arranged to control the flow of media across the sensor elements.

7. A sensor system according to claim 1, further comprising a structure defining wells on top of the sensor elements for separating groups of media.

8. A method of observing biological or chemical activity comprising providing a sample to be observed on or adjacent to a sensor system having a sensor system comprising a substrate and, integrated onto the substrate, a sensor element, the sensor element comprising one or more inductors, one or more electrochemical sensors, and one or more optical sensors, the sensor system further comprising a controller configured in use to drive the one or more inductors and to monitor outputs of the sensors in order to provide a sensor element result;

and,

influencing, for each sensor element, the sample using the one or more inductors and observing the electrochemical sensor output with the optical sensor output to determine one or more properties of the sample.

9. A method according to claim 8, wherein said sample is neural tissue and the activity is neural activity, the electrochemical sensor output corresponding to ions released from neurons, preferably corresponding to neurotransmitters released.

10. A method according to claim 9, wherein the or each inductor provides stimulation of one or more neurons.

11. A method according to claim 9 or 10, wherein one or more neurons are targeted by beam forming using a plurality of inductors.

12. A method according to claim 8, wherein the activity is a chemical reaction and the electrochemical sensor output corresponds to reaction intermediaries.

13. A method according to claim 8, wherein the activity corresponds to the insertion of one or more nucleotides at the end of a nucleotide chain.

14. A method according to claim 8, further comprising manipulating the sample using the one or more inductors.

15. A method according to claim 8, further comprising stimulating the media using the one or more inductors.

16. A method of calibrating a sensor system according to claim 8, further comprising reading a plurality of calibration values from a memory, using at least one calibration value per sensor element to modify a property of each sensor element, such that the sensor element outputs of the sensor system achieve a desired state.

17. A method according to claim 16, further comprising calculating the calibration values by comparing each sensor output in an initial state with a global parameter and then storing the calibration value in the memory.

18. A method according to claim 16, wherein the calculation of the calibration value is performed iteratively.

19. A method according to anyone of claims 16, wherein the calibration value determines a gate bias voltage of an ISFET of each sensor element.

20. A method according to claim 16, wherein the desired state is minimised mismatch between sensor output in the array.

21. A method according to claim 16, wherein the desired state is minimized sensor non-ideality.

22. A method according to claim 8, further comprising analyzing an output of an optical sensor of the or each sensor element to identify the presence of a sample on or adjacent to the optical sensor.

23. A sensor system comprising a substrate and integrated onto the substrate an array of sensor elements, each sensor element comprising:

one or more inductors;

one or more electrochemical sensors; and

one or more optical sensors, the system further comprising a controller configured in use to separately address each of the sensor elements to drive the respective inductors and receive outputs of the respective sensors.

24. A sensor system according to claim 23 and comprising one or more guide channels for guiding a sample to be analyzed across respective sensing surfaces of the sensor elements.

25. A sensor system according to claim 24, wherein each guide channel is integrated onto the substrate.

26. A sensor system according to claim 23 suitable for monitoring or conducting tests on one of a biological and biochemical sample.