SYSTEM AND METHOD FOR DETECTING SYMPTOMS OF HYPOGLYCEMIA

• US 20130102859A1
• Filed: 06/20/2011
• Published: 04/25/2013
• Est. Priority Date: 06/22/2010
• Status: Abandoned Application

• Current Assignee: Gili Medical Ltd.
• Original Assignee: Gili Medical Ltd.
• Inventors: Schechter, Amir
• Application Number:
  US13/805,815
• Publication Number:
  US 20130102859A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/6802 Sensor mounted on worn items
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B

Abstract

An improved system and method for detecting a hypoglycemic event of a diabetic individual is provided. The system of the invention includes at least three sensors for monitoring the respective physiological parameter selected from the following list: heart rate, motorial activity, respiring rate, vasoconstriction, temperature of the skin and galvanic resistance of the skin of the user. The system automatically alerts the user and/or a member of medical care personnel in a case that at least three different symptoms of a hypoglycemic event, each of which associated with a respective physiological parameter, simultaneously occur. According to the method of the present invention basal levels and basal rates of changes of the respective physiological parameters are generated and repeatedly updated. These basal levels and/or rates provides for detecting changes that go beyond predefined limits for determining a symptom of a hypoglycemic event which is associated with the respective physiological parameter.

Claims

1-11. -11. (canceled)

12. A method for non-invasively detecting a hypoglycemic event, the method comprising:

detecting a level of heart rate, motorial activity, peripheral vasoconstriction, and skin resistance;

comparing the detected levels of each of the heart rate, motorial activity, peripheral vasoconstriction, and skin resistance to a respective scale and assigning a respective score to each of the detected heart rate, motorial activity, peripheral vasoconstriction, and skin resistance; and

determining a hypoglycemic event when a combined score calculated from the respective scores reaches a predefined value.

13. The method of claim 12, wherein when a hypoglycemic event is determined an alarm is triggered.

14. The method of claim 12, wherein the respective scale of each of the heart rate, motorial activity, peripheral vasoconstriction, and skin resistance is predefined or experimentally derived.

15. The method of claim 12, wherein the score of the skin resistance is normalized to changes in ambient temperature.

16. The method of claim 12, wherein detecting a level of heart rate, motorial activity, peripheral vasoconstriction, and skin resistance is performed by three sensors.

17. The method of claim 16, wherein the three sensors comprise:

a skin resistance sensor, an accelerometer, and a light detector.

18. The method of claim 17, wherein the light detector is configured to detect heart rate, peripheral vasoconstriction or both.

19. The method of claim 16, wherein the three sensors are incorporated into a single wearable unit.

20. The method of claim 19, wherein the single wearable unit is a wristwatch.

21. The method of claim 12, wherein detecting a level of heart rate, motorial activity, vasoconstriction, and skin resistance is performed by two sensors.

22. The method of claim 21, wherein the two sensors comprise:

a skin resistance sensor and a light detector.

23. The method of claim 22, wherein the light detector is configured to detect heart rate, peripheral vasoconstriction, motorial activity or any combination thereof.

24. The method of claim 21, wherein the two sensors are incorporated into a single wearable unit.

25. The method of claim 24, wherein the single wearable unit is a wristwatch.

26. A system for non-invasively detecting a hypoglycemic event, said system comprising:

at least two sensors configured to detect levels of heart rate, motorial activity, peripheral vasoconstriction, and skin resistance;

a processor configured to;

compare each of the detected levels of the heart rate, motorial activity, peripheral vasoconstriction, and skin resistance with respective scales,

assign a respective score to each of the heart rate, motorial activity, peripheral vasoconstriction, and skin resistance; and

determine a hypoglycemic event when a combined score, calculated from the respective scores, reaches a predefined value.

27. The system of claim 26, further comprising an alarm configured to be activated when a hypoglycemic event is determined.

28. The system of claim 26, wherein the scale of each of the heart rate, motorial activity, peripheral vasoconstriction, and skin resistance is predefined or experimentally derived.

29. The system of claim 26, wherein the score of the skin resistance is normalized to changes in ambient temperature.

30. The system of claim 26, wherein said at least two sensors comprise:

a skin resistance sensor, an accelerometer and a light detector.

31. The system of claim 30, wherein said light detector is configured to detect heart rate, peripheral vasoconstriction or both.

32. The system of claim 26, wherein said at least two sensors comprise:

a skin resistance sensor and a light detector.

33. The system of claim 32, wherein said light detector is configured to detect heart rate, vasoconstriction, motorial activity or any combination thereof.

34. The system of claim 26, wherein said at least two sensors are incorporated into a single wearable unit.

35. The system of claim 34, wherein said single wearable unit is a wristwatch.

36. The system of claim 26, configured to detect said level of heart rate, said motorial activity, said peripheral vasoconstriction, and said skin resistance using only two sensors:

a skin resistance sensor and a light detector.