PORTABLE BLOOD FILTRATION DEVICES, SYSTEMS, AND METHODS
First Claim
1. A method for extracorporeal treatment of blood to remove a target substance, comprising:
- removing blood from a patient and passing the blood through a microfluidic channel, the microfluidic channel having microsieve wall filters therein;
extracting a cytoplasmic body-free blood fraction of the blood from the microfluidic channel by passing through the microsieve wall filters the a cytoplasmic body-free blood fraction including the target substance;
extracting at least some of the target substance from the removed cytoplasmic body-free fraction and returning the resulting cytoplasmic body-free fraction to the patient.
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Accused Products
Abstract
A blood filtration device, system, and method that can and selectively remove or reduce an unwanted, in certain cases unknown, substance from a patient'"'"'s blood stream. More specifically, a specific size or size range of unwanted substance is selectively removed. The unwanted substance includes one or more of a pathogen, a toxin, an activated cell, and an administered drug. The device and system employ a microfluidic separation device that minimizes thrombogenesis and can permit the use of anticoagulants to be avoided. The device or system can be portable and can include its own power supply. Sensors in the system may monitor for the presence and/or concentration of unwanted species including pathogens or drugs and invoke a blood cleansing process responsively to the sensor signals in closed loop control process. The control may combine the infusion of therapeutic agents into the blood of a patient as well.
23 Citations
41 Claims
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1. A method for extracorporeal treatment of blood to remove a target substance, comprising:
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removing blood from a patient and passing the blood through a microfluidic channel, the microfluidic channel having microsieve wall filters therein; extracting a cytoplasmic body-free blood fraction of the blood from the microfluidic channel by passing through the microsieve wall filters the a cytoplasmic body-free blood fraction including the target substance; extracting at least some of the target substance from the removed cytoplasmic body-free fraction and returning the resulting cytoplasmic body-free fraction to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for extracorporeal treatment of blood to remove a target substance, comprising:
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removing blood from a patient and passing the blood through a microfluidic channel having wall filters with a diffusing the target substance into a cytoplasmic body-free blood fraction; extracting and discarding the cytoplasmic body-free fraction from the microfluidic channel, the extracting including passing said fraction through a microsieve filter having a single pore size achieved by micromachining; and returning fresh plasma to the patient.
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15-33. -33. (canceled)
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34. A method for treating sepsis without use of anticoagulants, molecular labels, and/or specific binding chemistries, comprising:
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drawing blood from a patient using a closed loop system; detecting a particle in the drawn blood indicative of sepsis or oncoming sepsis using at least one non-fouling or substantially non-fouling sensor; treating the drawn blood using a plurality of microfluidic separation channels to selectively remove the particle; and returning to the patient cleaned blood having been subjected to said treating. - View Dependent Claims (35, 36, 37, 38, 40)
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39. (canceled)
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41-43. -43. (canceled)
Specification