Implantable Film/Mesh Composite

• US 20130102959A1
• Filed: 10/12/2012
• Published: 04/25/2013
• Est. Priority Date: 10/25/2011
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Stopek, Joshua, Elachchabi, Amin, Broom, Daniel
• Granted Patent: US 8,932,621 B2
• Time in Patent Office: Days
• US Class Current: 604/93.01
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61L 31/005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 23/12 Polypropene
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present disclosure relates to implantable medical devices which include at least one mesh and at least one film attached to the mesh along different portions of the mesh creating at least one aperture between the mesh and the film.

Claims

1. An implantable medical device comprising:

a first mesh having a first outer edge and a first inner edge,

a second mesh having a second outer edge and a second inner edge, wherein the first and second inner edges are removably affixed, and

a film having at least a first portion attached to the first outer edge of the first mesh and at least a second portion attached to the second outer edge of the second mesh.

2. The implantable medical device of claim 1 further comprising at least one therapeutic agent.

3. The implantable medical device of claim 2 wherein the at least one therapeutic agent comprises a drug selected from the group consisting of lidocaine, bupivacaine, capsaicin, tetracaine, procaine, dibucaine, sirolimus, taxol, chlorhexidine, polyhexamethylene, thiamylal sodium, thiopental sodium, ketamine, flurazepam, amobarbital sodium, phenobarbital, bromovalerylurea, chloral hydrate, phenyloin, ethotoin, trimethadione, primidone, ethosuximide, carbamazepine, valproate, acetaminophen, phenacetin, aspirin, sodium salicylate, aminopyrine, antipyrine, sulpyrine, mepirizole, tiaramide, perixazole, diclofenac, anfenac, buprenorphine, butorphanol, eptazocine, dimenhydrinate, difenidol, dl-isoprenaline, chlorpromazine, levomepromazine, thioridazine, fluphenazine, thiothixene, flupenthixol, floropipamide, moperone, carpipramine, clocapramine, imipramine, desipramine, maprotiline, chlordiazepoxide, clorazepate, meprobamate, hydroxyzine, saflazine, ethyl aminobenzoate, chlorphenesin carbamate, methocarbamol, acetylcholine, neostigmine, atropine, scopolamine, papaverine, biperiden, trihexyphenidyl, amantadine, piroheptine, profenamine, levodopa, mazaticol, diphenhydramine, carbinoxamine, chlorpheniramine, clemastine, aminophylline, choline, theophylline, caffeine, sodium benzoate, isoproterenol, dopamine, dobutamine, propranolol, alprenolol, bupranolol, timolol, metoprolol, procainamide, quinidine, ajmaline, verapamil, aprindine, hydrochlorothiazide, acetazolamide, isosorbide, ethacrynic acid, captopril, enalapril, delapril, alacepril, hydralazine, hexamethonium, clonidine, bunitrolol, guanethidine, bethanidine, phenylephrine, methoxamine, diltiazem, nicorandil, nicametate, nicotinic-alcohol tartrate, tolazoline, nicardipine, ifenprodil, piperidinocarbamate, cinepazide, thiapride, dimorpholamine, levallorphan, naloxone, hydrocortisone, dexamethasone, prednisolone, norethisterone, clomiphene, tetracycline, methyl salicylate, isothipendyl, crotamiton, salicylic acid, nystatin, econazole, cloconazole, vitamin B₁, cyclothiamine, vitamin B₂, vitamin B₃, vitamin B₅, vitamin B₆, vitamin B₇, vitamin B₉, vitamin B₁₂, vitamin C, nicotinic acid, folic acid, nicotinamide, calcium pantothenate, pantothenol, panthetin, biotin, ascorbic acid, tranexamic acid, ethamsylate, protamine, colchicine, allopurinol, tolazamide, glymidine, glybuzole, metoformin, buformin, orotic acid, azathioprine, lactulose, nitrogen mustard, cyclophophamide, thio-TEPA, nimustine, thioinosine, fluorouracil, tegafur, vinblastine, vincristine, vindesine, mitomycin C, daunorubicin, aclarubicin, procarbazine, cisplatin, methotrexate, benzylpenicillin, amoxicillin, penicillin, oxycillin, methicillin, carbenicillin, ampicillin, cefalexin, cefazolin, erythromycin, kitasamycin, chloramphenicol, thiamphenicol, minocycline, lincomycin, clindamycin, streptomycin, kanamycin, fradiomycin, gentamycin, spectinomycin, neomycin, vanomycin, tetracycline, ciprofloxacin, sulfanilic acid, cycloserine, sulfisomidine, isoniazid, ethambutol, acyclovir, gancyclovir, vidabarine, azidothymidine, dideoxyinosine, dideoxycytosine, morphine, codeine, oxycodone, hydrocodone, cocaine, pethidine, fentanyl, polymeric forms of any of the above drugs and any combinations thereof.

4. The implantable medical device of claim 2 wherein the at least one therapeutic agent is selected from the group consisting of bupivacaine and bupivacaine hydrochloride.

5. The implantable medical device of claim 1 further comprising at least one connector positioned on at least one of the first and second mesh.

6. The implantable medical device of claim 5 wherein the at least one connector comprises a grip-member.

7. The implantable medical device of claim 1 wherein the at least one connector comprises a barb.

8. The implantable medical device of claim 1 wherein the at least one connector comprises an adhesive.

9. The implantable medical device of claim 1, wherein the film comprises a biodegradable material.

10. The implantable medical device of claim 1 wherein the film comprises a copolymer of glycolide and caprolactone.

11. The implantable medical device of claim 1 wherein the film comprises a copolymer of glycolide, trimethylene carbonate, caprolactone and lactide.

12. The implantable medical device of claim 1 wherein the film comprises a copolymer of glycolide, dioxanone, and trimethylene carbonate.

13. The implantable medical device of claim 1, wherein the film comprises an aliphatic polyester.

14. The implantable medical device of claim 1, wherein the film comprises collagen.

15. The implantable medical device of claim 1, wherein at least one of the first and second mesh comprise a non-bioabsorbable material.

16. The implantable medical device of claim 1, wherein at least one of the first and second mesh comprise a non-bioabsorbable polyester.

17. The implantable medical device of claim 16, wherein at least one of the first and second mesh comprise polypropylene.

18. The implantable medical device of claim 1, wherein at least one of the first and second mesh comprise an animal-derived tissue.

19. The implantable medical device of claim 1, wherein at least one of the first and second mesh comprise an allograft or a xenograft.