APPLICATORS FOR STORING STERILIZING, AND DISPENSING AN ADHESIVE

• US 20130108352A1
• Filed: 11/02/2011
• Published: 05/02/2013
• Est. Priority Date: 11/02/2011
• Status: Active Grant

• Current Assignee: HB Fuller Medical Adhesive Technologies LLC
• Original Assignee: Adhezion Biomedical LLC (H.B. Fuller Co. (Indonesia))
• Inventors: Ruiz, Rafael Sr., Zhang, Sheng, Krauss, Martin
• Granted Patent: US 9,066,711 B2
• Time in Patent Office: Days
• US Class Current: 401/132
• CPC Class Codes: A46B 11/0075 Means integral with the brush for opening, puncturing or piercing sealed reservoirs, e.g. on insertion
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2090/0813 Accessories designed for easy sterilising, i.e. re-usable
• CPC Class Codes: A61M 35/003 Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003
• CPC Class Codes: A61M 35/006 using sponges, foams, absorbent pads or swabs as spreading means
• CPC Class Codes: B05C 17/00586 Means, generally located near the nozzle, for piercing or perforating the front part of a cartridge
• CPC Class Codes: B65D 35/36 for applying contents to surfaces brushes combined or associated with tubular containers A46B11/00
• CPC Class Codes: B65D 51/225 and further comprising a device first inhibiting displacement of the outer closure B65D51/223 takes precedence

Abstract

Applicators for storing, sterilizing, and dispensing adhesives are provided. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpolymerized for about twenty four months.

Claims

1. An applicator for storing and dispensing an adhesive comprising:

a) a container comprising walls defining a chamber having an opening at the distal end and fabricated from a material that is substantially impermeable to moisture and air, a distal seal, a middle seal, and a proximal seal, and a polymerizable cyanoacrylate monomer adhesive stored in the chamber between the proximal seal and the proximal end of the container;

b) a body comprising a flange comprising at least one hole, a channel in communication with the hole, extending distally through the body, and having an opening at the distal end, and optionally, a grip capable of constricting the channel when inward pressure is applied to the grip, wherein the proximal end of the flange is positioned between the middle seal and the proximal seal of the container and is capable of penetrating the proximal seal when the body and the container are compressed together;

c) a porous tip in communication with the opening at the distal end of the channel; and

d) optionally, a removable lock between the container and the body that prevents the body and the container from being compressed together and that when removed allows the body and the container to be compressed together;

wherein the applicator is activated by compressing the body and the container together whereupon the flange penetrates the proximal seal and allows the adhesive to flow into the hole, through the channel, and out of the porous tip.

2. The applicator of claim 1, wherein the adhesive is bioabsorbable.

3. The applicator of claim 1, wherein the adhesive comprises 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof.

4. The applicator of claim 1, wherein the walls of the container comprise an acrylonitrile copolymer.

5. The applicator of claim 4, wherein walls of the container comprise a plurality of layers, and the acrylonitrile copolymer comprises the inner-most layer of the wall such that the acrylonitrile copolymer layer contacts the adhesive stored in the container.

6. The applicator of claim 4, wherein the walls of the container comprise an acrylonitrile copolymer and methyl acrylate.

7. The applicator of claim 1, wherein the applicator has been sterilized by gamma, electron beam, or x-ray radiation, and the adhesive is capable of remaining substantially unpolymerized when stored within the container for a period of at least about twelve months following sterilization.

8. The applicator of claim 1, wherein the applicator has been sterilized by gamma, electron beam, or x-ray radiation, and the adhesive is capable of remaining substantially unpolymerized when stored within the container for a period of at least about twenty four months following sterilization.

9. The applicator of claim 1, wherein the porous tip comprises a swab, sponge, foam, or a brush.

10. The applicator of claim 1, further comprising a tip overlay.

11. An applicator for storing and dispensing an adhesive comprising:

a) a flexible handle comprising a housing for containing a removable adhesive container and a female end of a luer lock at the distal end of the handle;

b) a body comprising a male end of a luer lock at the proximal end of the body and capable of connecting with the female end at the distal end of the handle, and a channel extending distally through the body, and having an opening at the distal end;

c) a porous tip in communication with the opening at the distal end of the channel; and

d) a removable adhesive container fabricated from a material that is substantially impermeable to moisture and air and capable of fitting within the housing, comprising a frangible seal at the distal end of the container, and a polymerizable cyanoacrylate monomer adhesive stored in the container;

wherein the applicator is activated by compromising the frangible seal whereupon the adhesive may flow into and through the channel and out of the porous tip.

12. The applicator of claim 11, wherein the adhesive is bioabsorbable.

13. The applicator of claim 11, wherein the adhesive comprises 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof.

14. The applicator of claim 11, wherein the container is fabricated from an acrylonitrile copolymer.

15. The applicator of claim 11, wherein the container is a stick pack container.

16. The applicator of claim 11, wherein the frangible seal comprises aluminum foil laminated with an acrylonitrile copolymer.

17. The applicator of claim 11, wherein the applicator has been sterilized by gamma, electron beam, or x-ray radiation, and the adhesive is capable of remaining substantially unpolymerized when stored within the container for a period of at least about twelve months following sterilization.

18. The applicator of claim 11, wherein the applicator has been sterilized by gamma, electron beam, or x-ray radiation, and the adhesive is capable of remaining substantially unpolymerized when stored within the container for a period of at least about twenty four months following sterilization.

19. The applicator of claim 11, wherein the porous tip comprises a swab, sponge, foam, or a brush.

20. The applicator of claim 11, further comprising a tip overlay.

21. An applicator for storing and dispensing an adhesive comprising:

a) a container comprising walls defining a chamber having an opening at the distal end and fabricated from a material that is substantially impermeable to moisture and air, a frangible seal covering the opening, a polymerizable cyanoacrylate monomer adhesive stored in the chamber, and optionally, screw threads on the exterior of the walls;

b) a body comprising a cavity at the proximal end, a channel in communication with the cavity, extending distally through the body, and having an opening at the distal end, a grip capable of constricting the channel when inward pressure is applied to the grip, at least one projection in the cavity, wherein the projection is capable of penetrating the frangible seal when the body and the container are compressed together, and optionally, screw threads on the walls of the cavity;

c) a porous tip in communication with the opening at the distal end of the channel; and

d) optionally, a removable lock between the container and the body that prevents the body and the container from being compressed together and that when removed allows the body and the container to be compressed together;

wherein the applicator is activated by compressing the body and the container together whereupon the projection penetrates the frangible seal and allows the adhesive to flow into and through the channel and out of the porous tip.

22. The applicator of claim 21, wherein the adhesive is bioabsorbable.

23. The applicator of claim 21, wherein the adhesive comprises 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof.

24. The applicator of claim 21, wherein the container is fabricated from an acrylonitrile copolymer.

25. The applicator of claim 21, wherein the frangible seal comprises aluminum foil laminated with an acrylonitrile copolymer.

26. The applicator of claim 21, wherein the applicator has been sterilized by gamma, electron beam, or x-ray radiation, and the adhesive is capable of remaining substantially unpolymerized when stored within the container for a period of at least about twelve months following sterilization.

27. The applicator of claim 21, wherein the applicator has been sterilized by gamma, electron beam, or x-ray radiation, and the adhesive is capable of remaining substantially unpolymerized when stored within the container for a period of at least about twenty four months following sterilization.

28. The applicator of claim 21, wherein the porous tip comprises a swab, sponge, foam, or a brush.

29. The applicator of claim 21, wherein applicator is activated by screwing the body and the container together whereupon the projection penetrates the frangible seal and allows the adhesive to flow into and through the channel and out of the porous tip.

30. The applicator of claim 21, further comprising a tip overlay.