METHODS FOR MANUFACTURING MOLECULAR ARRAYS
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Abstract
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for example, directly to manufacture or “print” peptide arrays from a DNA array; however, the methods are applicable to a wide range of manufacturing applications for use any time multiple copies of an array needs to be printed.
102 Citations
38 Claims
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1-30. -30. (canceled)
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31. A method of manufacturing an array of products on a substrate comprising:
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providing partitioned reaction volumes on the substrate, wherein the partitioned reaction volumes are partitioned by surface energetic barriers; generating products by one or more enzymatic processes in the partitioned reaction volumes; and immobilizing the products from the partitioned reaction volumes on capture moieties on the substrate, wherein partitioning of the reaction volumes prevents diffusion of products between them. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
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Specification