ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1
First Claim
Patent Images
1. An isolated antibody or antibody fragment which binds to human PD-1 comprising:
- a. at least one CDR selected from the group consisting of SEQ ID NOs;
9, 10, 11, 15, 16 and 17, or a variant of any said sequence; and
/orb. at least one a CDR selected from the group consisting of SEQ ID NOs;
12, 13, 14, 18, 19 and 20, or a variant of any said sequence.
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Abstract
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.
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Citations
10 Claims
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1. An isolated antibody or antibody fragment which binds to human PD-1 comprising:
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a. at least one CDR selected from the group consisting of SEQ ID NOs;
9, 10, 11, 15, 16 and 17, or a variant of any said sequence; and
/orb. at least one a CDR selected from the group consisting of SEQ ID NOs;
12, 13, 14, 18, 19 and 20, or a variant of any said sequence. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification