METHOD AND APPARATUS FOR MEDICAL IMAGING USING COMBINED NEAR-INFRARED OPTICAL TOMOGRAPHY, FLUORESCENT TOMOGRAPHY AND ULTRASOUND
First Claim
Patent Images
1. A method comprising:
- obtaining an image of a tissue volume with a probe comprising;
an ultrasound transducer that is operative to provide an on-site estimation of inclusion size and location;
a first emitter and a first detector;
the first emitter having light of a wavelength of about 400 to about 900 nanometers;
the first detector detecting light of a wavelength of about 400 to about 900 nanometers;
a source circuit connected in operational communication to the emitter;
a detector circuit connected in operational communication to the detector; and
a central processing unit connected to the source circuit and the detector circuit;
scanning the tissue volume with light having a wavelength of about 400 to about 900 nanometers;
the tissue volume comprising a first layer and a second layer;
segmenting the scanned tissue volume into an inclusion region comprising a plurality of first voxels and a background region comprising a plurality of second voxels;
the volume of each second voxel being larger than the volume of each first voxel;
reconstructing the image using the equation (2)
[Usd]M×
1=[WL,WB]M×
N×
[ML,MB]TN×
1
(2)where WL and WB are weight matrices for the inclusion and background regions, respectively;
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Abstract
Methods and apparatus for medical imaging using diffusive optical tomography and fluorescent diffusive optical tomography and ultrasound are disclosed. In one embodiment, the probe comprises emitters and detectors that are inclined at an angle of about 1 to about 30 degrees to a surface of the probe that contacts tissue. In another embodiment, the scanned volume is divided into an inclusion region and a background region. Different voxel sizes are used in the inclusion region and the background region. Appropriate algorithms facilitate a reconstruction of the inclusion region to determine structural and functional features of the inclusion.
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Citations
20 Claims
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1. A method comprising:
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obtaining an image of a tissue volume with a probe comprising; an ultrasound transducer that is operative to provide an on-site estimation of inclusion size and location; a first emitter and a first detector;
the first emitter having light of a wavelength of about 400 to about 900 nanometers;
the first detector detecting light of a wavelength of about 400 to about 900 nanometers;a source circuit connected in operational communication to the emitter; a detector circuit connected in operational communication to the detector; and a central processing unit connected to the source circuit and the detector circuit; scanning the tissue volume with light having a wavelength of about 400 to about 900 nanometers;
the tissue volume comprising a first layer and a second layer;segmenting the scanned tissue volume into an inclusion region comprising a plurality of first voxels and a background region comprising a plurality of second voxels;
the volume of each second voxel being larger than the volume of each first voxel;reconstructing the image using the equation (2)
[Usd]M×
1=[WL,WB]M×
N×
[ML,MB]TN×
1
(2)where WL and WB are weight matrices for the inclusion and background regions, respectively; - View Dependent Claims (2, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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3. The method of claim 3, wherein the reconstructing each layer comprises using the Equations (3), (4) and (5):
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[Usd]M×
1=[WL(ROI#1),WB1 ,WB1 (other-t arg et-layers),WB(BG-layers)]×
[ML(ROI#1),MB1 ,MB1 (other-t arg et-layers),MB(BG-layers)]T
(3)
[Usd]M×
1=[WL(ROI#2),WB2 ,WB2 (other-t arg et-layers),WB(BG-layers)]×
[ML(ROI#2),MB2 ,MB2 (other-t arg et-layers)]T
(4)
[Usd]M×
1=[WL(ROI#N),WBN (other-t arg et-layers),WB(BG-layers)]×
[ML(ROI#N),MBN ,MBN (other-t arg et-layers), MB(BG-layers)]T
(5)where WL(ROI#1), WL(ROI#2), . . . , WL(ROI#N), are weight matrices for the region of interest #1, #2 and #N respectively, and WB 1 , WB2 , . . . , WBN are weight matrices of corresponding background regions in the same depth layer. WB1 (other-t arg et-layers), WB2 (other-t arg et-layers), WBN (other-t arg et-layers), are weight matrices of other target layers excluding the corresponding region of interest # target layer, and WB(BG-layers) is the weight matrix of the common background layers respectively.- View Dependent Claims (4)
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16. An apparatus for medical imaging using diffusive optical tomography and fluorescent diffusive optical tomography comprising;
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a probe comprising a first emitter and a first detector;
the first emitter or the first detector being inclined at an angle θ
of up to about 30 degrees to a surface of the probe that contacts tissue;the probe comprising a an ultrasound transducer; a source circuit connected in operational communication to the emitter; a detector circuit connected in operational communication to the detector; a central processing unit connected to the source circuit and the detector circuit; a display operably connected to the central processing unit; and
,wherein the central processing unit is capable of processing information to provide diffusive optical tomography and fluorescent diffusive optical tomography. - View Dependent Claims (17, 18, 19, 20)
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Specification