METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE
First Claim
1. A method for preparing bioprosthetic tissue membrane material, comprising:
- selecting a tissue membrane having a fibrous side and a smooth side; and
removing material from the fibrous side of the selected membrane by ablating with a very short pulse duration laser to reduce thickness non-uniformity in the fibrous side.
1 Assignment
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Accused Products
Abstract
Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
27 Citations
23 Claims
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1. A method for preparing bioprosthetic tissue membrane material, comprising:
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selecting a tissue membrane having a fibrous side and a smooth side; and removing material from the fibrous side of the selected membrane by ablating with a very short pulse duration laser to reduce thickness non-uniformity in the fibrous side. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for fabricating a heart valve leaflet, comprising:
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selecting a bioprosthetic tissue membrane having a fibrous side and a smooth side and a non-uniform thickness; cross-linking the membrane; forming a heart valve leaflet from the cross-linked membrane to have an arcuate cusp edge and a free edge opposite the cusp edge; and removing material from the fibrous side of the heart valve leaflet by ablating with a laser to reduce thickness non-uniformity in the fibrous side. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for fabricating a heart valve with bioprosthetic tissue leaflets, comprising:
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selecting a bioprosthetic tissue membrane having opposite sides and a non-uniform thickness; cross-linking the membrane; subjecting the cross-linked membrane to a glycerin-based drying process; forming a heart valve leaflet from the membrane after the glycerin-based drying process to have a peripheral edge region, a free edge opposite the peripheral edge region, and a central region surrounded by the peripheral edge region and free edge; removing material from at least one side of the heart valve leaflet by ablating with a laser to reduce thickness non-uniformity; and attaching a plurality of the heart valve leaflets to a structural stent by connecting the peripheral edge regions of each leaflet to the structural stent. - View Dependent Claims (20, 21, 22, 23)
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Specification