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SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING

  • US 20130118127A1
  • Filed: 11/13/2012
  • Published: 05/16/2013
  • Est. Priority Date: 11/15/2011
  • Status: Active Grant
First Claim
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1. A method for producing silicone hydrogel contact lenses each having a crosslinked hydrophilic coating thereon, comprising the steps of:

  • (a) obtaining a silicone hydrogel contact lens;

    (b) applying a layer of carboxyl-containing polymeric material onto the silicone hydrogel contact lens;

    (c) placing the silicone hydrogel contact lens with the layer of carboxyl-containing polymeric material thereon into a lens package containing a packaging solution, wherein the packaging solution comprises one or more crosslinkable hydrophilic polymeric materials selected from the group consisting of (i) a water-soluble hydrophilic polymer polymeric material having epoxide groups, wherein the hydrophilic polymeric material is partial reaction product of a first multi-arm polyethyleneglycol having terminal epoxide groups and a first hydrophilicity-enhancing agent having at least one reactive functional group selected from the group consisting of amino group, carboxyl group, hydroxyl group, thiol group, and combination thereof, (ii) a second multi-arm polyethyleneglycol having terminal epoxide groups, (iii) a mixture of a third multi-arm polyethyleneglycol having terminal epoxide groups and a second hydrophilicity-enhancing agent having at least one reactive functional group selected from the group consisting of amino group, carboxyl group, hydroxyl group, thiol group, and combination thereof, and (iv) a combination thereof;

    (d) sealing the package;

    (e) autoclaving the sealed package with the silicone hydrogel contact lens therein at a temperature from about 115°

    C. to about 125°

    C. for at least about twenty minutes, thereby forming a non-silicone hydrogel coating on the silicone hydrogel contact lens, wherein the non-silicone hydrogel coating is a crosslinked polymeric material composed of the carboxyl-containing polymeric material crosslinked with the one or more crosslinkable material.

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