Multimodal Brain Sensing Lead
First Claim
1. An implantable medical lead with multimodal sensing capability, comprising:
- a lead body having a proximal portion and a distal portion, the lead body further characterized by at least one lumen extending substantially between the proximal portion and the distal portion, whereinthe proximal portion is configured to be connected to a power source, a ground and other electronics for acquiring measurements from a patient'"'"'s body, the distal portion having a plurality of components configurable with the power source, the ground and the other electronics to acquire a first sensor measurement corresponding to a first sensing modality and a second sensor measurement corresponding to a second sensing modality, the first and second sensing modalities being different from each other; and
a plurality of conductors extending through at least one lumen and, at the proximal portion, in operable communication with the power source, the ground and the other electronics and, at the distal portion, in operable and selectable communication with the plurality of components, a number of conductors of the plurality of conductors sufficient to enable acquisition of the first and second sensor measurements.
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Accused Products
Abstract
A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.
69 Citations
23 Claims
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1. An implantable medical lead with multimodal sensing capability, comprising:
a lead body having a proximal portion and a distal portion, the lead body further characterized by at least one lumen extending substantially between the proximal portion and the distal portion, wherein the proximal portion is configured to be connected to a power source, a ground and other electronics for acquiring measurements from a patient'"'"'s body, the distal portion having a plurality of components configurable with the power source, the ground and the other electronics to acquire a first sensor measurement corresponding to a first sensing modality and a second sensor measurement corresponding to a second sensing modality, the first and second sensing modalities being different from each other; and a plurality of conductors extending through at least one lumen and, at the proximal portion, in operable communication with the power source, the ground and the other electronics and, at the distal portion, in operable and selectable communication with the plurality of components, a number of conductors of the plurality of conductors sufficient to enable acquisition of the first and second sensor measurements. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An implantable brain lead comprising:
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a proximal portion; a distal portion; a lead body characterized by at least one lumen extending substantially between the proximal portion and the distal portion, the proximal portion adapted to be connected to a device with a control module, a signal generator and a signal processor, the distal portion having a plurality of components adapted to rest adjacent to or within brain tissue; and a number of conductors extending in the at least one lumen to operably connect the plurality of components, either directly or indirectly, with the device, and wherein a lead comprising the lead body is configurable to acquire measurements from the brain tissue in at least two different sensing modalities. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A method of configuring a system including a sensor-bearing implantable medical lead and a device adapted to interface with the sensor-bearing implantable medical lead to acquire measurements corresponding to activity in or near a brain in at least two distinct sensing modalities, comprising;
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forming the sensor-bearing implantable medical lead with a substantially cylindrical lead body having a proximal portion and a distal portion, the lead body further formed with at least one lumen extending substantially between the proximal portion and the distal portion; providing a plurality of connectors in the proximal portion, each connector of the plurality of connectors adapted to be connected to one or more of a power source, a ground, or other electronics for acquiring a first set of measurements corresponding to a first sensing modality and for acquiring a second set of measurements corresponding to a second sensing modality, the first and second sensing modalities being different from each other; providing a plurality of components in the distal portion, at least one of the plurality of components adapted to be used in acquiring the first set of measurements and at least one of the plurality of components adapted to be used in acquiring the second set of measurements; providing a plurality of conductors extending through the at least one lumen and adapted to, at the proximal portion, be operably and selectively connected to the power source, the ground and the other electronics and, at the distal portion, to be operably and selectively connected with the plurality of components, a number of conductors of the plurality of conductors sufficient to enable acquisition of the first set and the second set of measurements; and providing a releasable connection between the pluralities of connectors in the proximal portion of the sensor-bearing implantable medical lead to the device, the device adapted to provide the power, the ground and the other electronics for acquiring the first set of measurements and the second set of measurements. - View Dependent Claims (18, 19, 20, 21, 22)
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23. A system for acquiring measurements corresponding to brain activity in multiple sensing modalities comprising:
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an implantable medical lead comprising; a lead body with a substantially circular cross-section and having a proximal portion and a distal portion, the lead body further characterized by at least one lumen extending substantially between the proximal portion and the distal portion; a plurality of components in the distal portion, at least one of the plurality of components adapted to be used in acquiring one or more sets of measurements corresponding to different sensing modalities; a plurality of conductors extending through the at least one lumen and configured to, at the distal portion, to be operably and selectively connected with the plurality of components and, at the proximal portion, to be operably and selectively connected to an implantable medical device, a number of conductors of the plurality of conductors sufficient to enable acquisition of each set of measurements of the one or more sets of measurements, wherein the implantable medical device comprises; a plurality of receptacles adapted to selectively communicate with the plurality of conductors in the implantable medical lead; a signal processor configured to process signals received from the plurality of conductors in the implantable medical lead to acquire one or more of the one or more sets of measurements; a signal generator to provide one or more signals through the plurality of conductors in the implantable medical lead to acquire one or more of the one or more sets of measurements; a memory to store information corresponding to any or all of the signals received from the plurality of conductors, the signals processed by the signal processor and the signals generated by the signal generator; a power source;
a system ground; anda control module configured to control functioning of at least the signal processor, the signal generator, the memory, and the power source; and a releasable connector adapted to connect the plurality of conductors in the implantable medical lead with the plurality of receptacles in the implantable medical device.
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Specification