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FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES

  • US 20130129628A1
  • Filed: 11/21/2012
  • Published: 05/23/2013
  • Est. Priority Date: 11/21/2011
  • Status: Active Grant
First Claim
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1. A method of functionalizing second harmonic generating probe nanostructure comprising:

  • providing a probe nanostructure formed from a nanocrystalline material capable of exposing free surface hydroxyls, the probe nanostructure defining an outer surface and having no inversion symmetry such that it generates a second harmonic emission when radiated by an external excitation source;

    hydroxylating the probe nanostructure to form an activated outer surface thereof;

    attaching a plurality of modifying molecules having amine terminal groups to the hydroxylates of the activated outer surface of the probe nanostructure to form a functionalization platform on said outer surface of the probe nanostructure; and

    functionalizing the amine terminal groups of the functionalization platform with a plurality of functionalization molecules to form a functionalized probe nanostructure.

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