CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF
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Abstract
The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
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Citations
30 Claims
- 1. A compound of formula I:
- 2. A compound of formula IIa:
- 3. A compound of formula IIIa:
- 4. A compound of formula IIb:
- 5. A compound of formula IIIb:
- 6. A compound of formula IIc:
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7. A compound of formula IIIc:
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8. A compound of formula lid:
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9. A compound of formula IIId:
- 23. A compound, or a pharmaceutically acceptable salt or solvate thereof, selected from:
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24. A compound, or a pharmaceutically acceptable salt or solvate thereof, selected from:
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27. A compound, or a pharmaceutically acceptable salt or solvate thereof, selected from:
Specification