TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER
First Claim
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1. A pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient;
- (ii) an opioid antagonist and/or an aversive agent;
(iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol; and
(a) further comprising (iv) an anionic polymer;
and/or(b) having a storage stability at 40°
C. of at least 3 months.
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Abstract
The invention relates to a pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient; (ii) an opioid antagonist and/or an aversive agent; (iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol; and (a) further comprising (iv) an anionic polymer; and/or (b) having a storage stability at 40° C. of at least 3 months.
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15 Claims
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1. A pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising (i) a pharmacologically active ingredient;
- (ii) an opioid antagonist and/or an aversive agent;
(iii) a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol; and(a) further comprising (iv) an anionic polymer; and/or (b) having a storage stability at 40°
C. of at least 3 months. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- (ii) an opioid antagonist and/or an aversive agent;
Specification