LEADLESS SYSTEM FOR DEEP BRAIN STIMULATION USING TIME REVERSAL ACOUSTICS

• US 20130131754A1
• Filed: 01/14/2013
• Published: 05/23/2013
• Est. Priority Date: 09/10/2005
• Status: Active Grant

• Current Assignee: Armen P. Sarvazyan
• Original Assignee: Armen P. Sarvazyan
• Inventors: Sarvazyan, Armen P.
• Granted Patent: US 8,649,876 B2
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61B 2017/00411 actuated by application of energy from an energy source outside the body
• CPC Class Codes: A61B 2017/3413 guided by ultrasound
• CPC Class Codes: A61B 2034/2063 Acoustic tracking systems, e.g. using ultrasound
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 2090/3929 Active markers
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37217 characterised by the communication link, e.g. acoustic or tactile
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

A leadless Deep Brain Stimulation system includes an implantable stimulator configured to convert incoming acoustic energy into an electric stimulation signal. The acoustic energy is provided by one or more external transmitters acoustically coupled to a head of the subject. To focus ultrasound energy onto the location of the stimulator, a wireless beacon (including a piezoelectric receiving transducer and an RF emitting antenna) is incorporated with the stimulator for providing an electromagnetic feedback signal to the external controller. The external controller is configured to send an initial unfocused acoustic signal towards the stimulator and receive the electromagnetic radiofrequency feedback signal generated by the receiving piezotransducer when affected by the acoustic signal after reverberation in the skull. This signal is then time-reversed and used to send a second signal towards the stimulator. This signal is inherently focused on the site of the stimulator and is configured to carry sufficient energy to operate the stimulator for DBS purposes.

Claims

1. A leadless system for deep brain stimulation of a subject based on time-reversal acoustics, the system comprising:

a first implantable stimulator in a hermetically sealed housing, said stimulator in turn comprising;

a first piezoelectric receiving transducer,

an emitting antenna configured for emitting a radiofrequency feedback signal, said emitting antenna is operably coupled to said piezoelectric receiving transducer,

an internal electrical circuit with an input operably coupled to said piezoelectric receiving transducer, said internal electrical circuit configured to be powered by said piezoelectric receiving transducer and to generate an electrical stimulation signal for deep brain stimulation, and

a first stimulating electrode operably coupled to an output of said internal electrical circuit, said first stimulating electrode configured to be in electrical contact with a first target brain portion of said subject, and

an external assembly comprising;

a time-reversal controller,

a radiofrequency receiving antenna,

a radiofrequency signal receiver with an input operably coupled with said radiofrequency receiving antenna and an output operably coupled with an input of said time-reversal controller,

an emitting acoustic transducer with an input operably coupled to an output of said time-reversal electronic unit,

wherein said external assembly is configured to emit a first initial unfocused acoustic wave signal, said first piezoelectric receiving transducer is configured to receive said first unfocused acoustic wave signal after reverberation in a skull of the subject and generate an electromagnetic radiofrequency feedback signal, said external assembly is further configured to receive said radiofrequency feedback signal, time-reverse thereof and generate a first driving signal to cause said emitting acoustic transducer to send a first acoustic wave signal focused on said first piezoelectric receiving transducer to generate electrical energy sufficient to operate said first implantable stimulator for the purpose of deep brain stimulation.

2. The system as in claim 1, wherein said first unfocused wave signal and said first focused acoustic wave signal are emitted at a first central frequency in a range from 30 kHz to 500 kHz.

3. The system as in claim 1 further comprising a second implantable stimulator having a second piezoelectric receiving transducer and a second stimulating electrode placed in electrical contact with a second target brain portion of said subject.

4. The system as in claim 3, wherein said external assembly is configured to generate said first unfocused acoustic wave signal and said first focused acoustic wave signal at said first central frequency corresponding to a resonance frequency of said first piezoelectric receiving transducer,

said external assembly is further configured to generate a second unfocused acoustic wave signal, time-reverse a second received radiofrequency feedback and generate a second focused acoustic wave signal at a second central frequency corresponding to a resonance frequency of said second piezoelectric receiving transducer,

whereby said external assembly is configured for selective deep brain stimulation at more than one target brain portion of the subject.

5. The system as in claim 4, wherein one of said first central frequency or said second central frequency is selected to exceed the other by at least 20% while both of said first and second central frequencies are selected in a range from 30 kHz to 500 kHz.

6. The system as in claim 1 further comprising an acoustic coupling media on said emitting acoustic transducer.

7. The system as in claim 1, wherein said external assembly further comprises a plurality of individual emitting acoustic transducers.

8. The system as in claim 7, wherein said external assembly further comprising an external reverberator, whereby said first initial unfocused acoustic wave is reaching said first piezoelectric receiving transducer after reverberation in both said external reverberator and said skull of said subject.

9. The system as in claim 8, wherein at least some of said plurality of individual acoustic transducers are attached and operatively coupled to said external reverberator.

10. The system as in claim 7, wherein said time-reversal controller is configured to activate said individual acoustic transducers to generate initial unfocused acoustic wave signals one-at-a-time, said time-reversal controller is further configured to receive respective radiofrequency feedback signals one-at-a-time and generate respective individual time-reversed driving signals for each individual emitting acoustic transducer, said time-reversal controller is further configured to operate all of said individual emitting acoustic transducers synchronously to generate said focused acoustic wave signal and to energize said first implantable stimulator.

11. The system as in claim 9, wherein said external assembly comprises a left external reverberator and at least one left emitting transducer operatively coupled thereto, together said left external reverberator and said at least one left emitting transducer forming a left emitting transmitter, said external assembly further including a right external reverberator and at least one right emitting transducer operatively coupled thereto, together said right external reverberator and said at least one right emitting transducer forming a right emitting transmitter.

12. The system as in claim 11, wherein said left emitting transmitter and said right emitting transmitter are enclosed in a hat sized to be firmly placed over the head of the subject.

13. The system as in claim 12, wherein the position of said left emitting transmitter and said right emitting transmitter in said hat is selected to assure their respective placement adjacent to left and right temporal bones of the skull when the subject wears said hat.

14. The system as in claim 11, wherein said left emitting transmitter and said right emitting transmitter are attached to a U-shaped elastic holder, said holder is shaped and sized to be placed over the head of the subject and retain said emitting transmitters next to the respective temporal bones of the subject.

15. The system as in claim 1, wherein said external assembly further including a user interface configured to provide manual control to start, stop, and adjust said deep brain stimulation.

16. The system as in claim 15, wherein said user interface is configured for activation of a deep brain stimulation session with preset parameters and for a preset duration, whereby said system is configured for “

on demand”

activation by the subject.

17. The system as in claim 15 further including a wireless controller configured for wireless communication with said external assembly, said wireless controller includes at least a portion of said user interface.

18. The system as in claim 1, wherein said internal electrical circuit is configured to generate said electrical stimulation signal at a frequency from 0 to 400 Hz, at a pulse width from 20 to 700 ms, at a voltage from 0 to 15V and in a mode of operation selected from a group consisting of continuous stimulation, intermittent stimulation, and on-demand stimulation.

19. A method for leadless deep brain stimulation of a subject, said method including the following steps:

a. providing an implantable stimulator at the target brain portion of said subject and an external assembly having at least one emitting acoustic transducer acoustically coupled to a head of said subject;

b. generating an initial unfocused acoustic signal using said emitting acoustic transducer;

c. reverberating said initial unfocused acoustic signal inside said head of said subject using a skull of said subject as a reverberation chamber;

d. receiving said initial unfocused acoustic signal by said implantable stimulator and generating an electromagnetic radiofrequency feedback signal;

e. recording said radiofrequency feedback signal by said external assembly;

f. time-reversing said radiofrequency feedback signal to generate a time-reversed signal;

g. generating a driving signal using said time-reversed signal;

h. emitting by said emitting acoustic transducer of an acoustic wave signal focused on said implantable stimulator to provide energy for operating thereof to generate an electrical signal suitable for deep brain stimulation of said subject.

20. A method of operating a leadless stimulator implanted in a head of a subject for the purposes of deep brain stimulation, said method including the following steps:

a. generating an initial unfocused acoustic signal by an external emitting acoustic transducer, said transducer acoustically coupled to said head of the subject;

b. causing said initial unfocused acoustic signal to reverberate in said head of said subject;

c. receiving said unfocused acoustic signal by said implanted stimulator;

d. generating a radiofrequency feedback signal by said implanted stimulator;

e. time-reversing of said radiofrequency feedback signal, and

f. emitting an acoustic wave signal focused on said implanted stimulator for providing energy thereto, said focused acoustic wave signal is formed using said time-reversing of said radiofrequency feedback signal.