Method and System for Multi-Scale Anatomical and Functional Modeling of Coronary Circulation
First Claim
1. A method, comprising:
- generating a patient-specific anatomical model of coronary arteries and the heart from medical image data of a patient;
generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model; and
simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation.
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Abstract
A method and system for multi-scale anatomical and functional modeling of coronary circulation is disclosed. A patient-specific anatomical model of coronary arteries and the heart is generated from medical image data of a patient. A multi-scale functional model of coronary circulation is generated based on the patient-specific anatomical model. Blood flow is simulated in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. Hemodynamic quantities, such as fractional flow reserve (FFR), are computed to determine a functional assessment of the stenosis, and virtual intervention simulations are performed using the multi-scale function model of coronary circulation for decision support and intervention planning.
140 Citations
40 Claims
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1. A method, comprising:
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generating a patient-specific anatomical model of coronary arteries and the heart from medical image data of a patient; generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model; and simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An apparatus comprising:
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means for generating a patient-specific anatomical model of coronary arteries and the heart from medical image data of a patient; means for generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model; and means for simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
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32. A non-transitory computer readable medium storing computer program instructions, which when operated on a processor cause the processor to perform operations comprising:
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generating a patient-specific anatomical model of coronary arteries and the heart from medical image data of a patient; generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model; and simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40)
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Specification